单项式全胸腔镜肺叶切除手术对肺癌患者氧自由基及血管内皮生长因子的影响  

Effects of Single‐Direction Thoracoscopic Lobectomy on Oxygen Free Radicals and Vascular En‐dothelial Growth Factor in Lung Cancer Patients

作　　者：邓永[1] 施进[1] 杨文刚[1] 沈楠林 吴树强[2] 沈蓝 DENG Yong;SHI Jin;YANG Wen‐gang(Department of Thoracic Surgery,People's Hospital of Sheyang County,Jiangsu Sheyang 224300)

机构地区：[1]射阳县人民医院胸外科,江苏射阳224300 [2]西安医学院第一附属医院,陕西西安710000 [3]云南省滇南中心医院急诊医学部,云南滇江661199

出　　处：《医学临床研究》2020年第5期689-692,共4页Journal of Clinical Research

摘　　要：[目的]探讨单向式全胸腔镜肺叶切除手术对肺癌患者氧自由基及血管内皮生长因子的影响.[方法]回顾性分析在本院诊治的136例肺癌患者的临床资料,按照治疗方法不同分为胸腔镜组(接受单向式全胸腔镜肺叶切除手术)和对照组(接受开胸肺癌根治术).比较两组患者手术时间、出血量、胸腔引流量、住院时间、并发症发生率及手术前后24 h血清超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-px)、血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)、C-反应蛋白(CRP)水平.[结果]胸腔镜组患者手术时间、出血量、胸腔引流量及住院时间均少于对照组(P<0.05);术后24h,胸腔镜组患者血清SOD及GSH-px水平均显著高于对照组(P<0.05),MDA、VEGF、MMP-9及CRP水平低于对照组(P<0.05);胸腔镜组患者并发症发生率低于对照组(P<0.05).[结论]单向式全胸腔镜肺叶切除手术治疗肺癌的疗效显著,对患者的创伤较小,可减轻患者氧化应激反应,减少V EG F的表达,且并发症发生率低,值得临床推广应用.[Objective]To explore the effects of single‐direction thoracoscopic lobectomy on oxygen radi‐cals and vascular endothelial growth factor in patients with lung cancer.[Methods]The clinical data of 136 pa‐tients with lung cancer treated in our hospital were retrospectively analyzed and divided into thoracoscopic group(underwent single‐direction thoracoscopic lobectomy)and control group(underwent radical thoracoto‐my)according to the treatment methods.Operation time,blood loss,thoracic drainage and hospitalization time were compared between the two groups.Serum levels of SOD,MDA,GSH‐px,VEGF,MMP‐9 and CRP were compared between the two groups before and 24h after surgery.Postoperative complications were compared between the two groups.[Results]The operation time,bleeding volume,pleural drainage and hospi‐talization time of patients in the thoracoscopic group were lower than those in the control group(P<00.5);the serum SOD and GSH‐px levels of patients in the thoracoscopic group were significantly higher than those in the control group(P<00.5),and the MDA,VEGF,MMP‐9 and CRP levels were lower than those in the control group(P<00.5)[.Conclusion]Single‐direction thoracoscopic lobectomy is effective in the treatment of lung cancer.the trauma to patients is small,which can reduce the oxidative stress response of patients and re‐duce the expression of VEGF,and the incidence of complications is low,which is worthy of clinical applica‐tion.

关 键 词：肺肿瘤/外科学 肺切除术 胸腔镜检查 

分 类 号：R734.2[医药卫生—肿瘤]