应用PEM-D系统评估阿帕替尼治疗晚期乳腺癌患者后整体心身变化及疗效观察  

Application of PEM-D system to evaluate the psychosomatic changes and efficacy in patients with advanced breast cancer treated with apatinib

作　　者：李义慧[1] 周洋 刘媛媛 王建功[1] Li Yihui;Zhou Yang;Liu Yuanyuan;Wang Jiangong(The First Department of Tumor Comprehensive Treatment,Tangshan People's Hospital,Hebei Province,Tangshan 063000,China)

机构地区：[1]河北省唐山市人民医院肿瘤综合治疗一科,063000

出　　处：《中国医药》2020年第6期894-897,共4页China Medicine

基　　金：河北省医学科学研究重点课题计划(20181208)。

摘　　要：目的应用PEM-D系统评估晚期乳腺癌患者经阿帕替尼治疗后的整体心身变化并观察其临床疗效。方法选取2017年10月至2018年12月河北省唐山市人民医院收治的56例晚期乳腺癌患者,所有患者均给予口服阿帕替尼联合卡培他滨治疗。应用PEM-D心身整体诊疗系统结合90项症状自评量表(SCL-90)、广泛性焦虑量表(GAD-7)、患者健康问卷(PHQ-9)、匹兹堡睡眠治疗指数(PSQI)评估患者的治疗前后的心身变化,并观察近期疗效。结果患者的客观缓解率为39.3%(22/56),疾病控制率为67.9%(38/56)。治疗后患者的压力指数、疲劳指数较治疗前明显降低[(48.6±1.1)分比(60.5±1.8)分、(83.9±0.6)分比(92.5±0.4)分],放松指数较治疗前明显增加[(65.0±1.0)分比(61.1±1.2)分],差异均有统计学意义(均P<0.05),PEM-D诊疗系统治疗前后稳定指数均较好,差异无统计学意义(P>0.05)。治疗后SCL-90、GAD-7、PHQ-9、PSQI评分均治疗前明显下降,差异均有统计学意义(均P<0.01)。结论PEM-D系统能够很好地评估患者心身变化。阿帕替尼联合卡培他滨治疗晚期乳腺癌患者具有较好的近期疗效,同时很好地改善了患者的精神心理问题。Objective To evaluate the psychosomatic changesand efficacy of apatinib in patients with advanced breast cancer using PEM-D system.Methods Totally 56 patients with advanced breast cancer admitted to Tangshan People's Hospital,Hebei Province from October 2017 to December 2018 were selected.All patients were treated with apatinib and capecitabine.PEM-D system,Symptom Checklist-90(SCL-90),Generalized Anxiety Disorder-7(GAD-7),Patient Health Questionnaire-9(PHQ-9)and Pittsburgh Sleep Quality Index(PSQI)were used to evaluate the psychosomatic changes and short-term outcomes.Results The objective response rate was 39.3%(22/56)and the disease control rate was 67.9%(38/56).After treatment,pressure index and fatigue index significantly decreased and relaxation index significantly increased compared with those before treatment[(48.6±1.1)vs(60.5±1.8),(83.9±0.6)vs(92.5±0.4),(65.0±1.0)vs(61.1±1.2)](all P<0.05).PEM-D system showed similar stability indexes before and after treatment(P>0.05).Scores of SCL-90,GAD-7,PHQ-9 and PSQI significantly decreased after treatment(all P<0.01).Conclusions PEM-D system can evaluate the psychosomatic changes of patients.Apatinib combined with capecitabine is effective in treating advanced breast cancer and improving the mental and psychological disorders of patients.

关 键 词：晚期乳腺癌 PEM-D系统 阿帕替尼 心身变化 

分 类 号：R737.9[医药卫生—肿瘤]