前列地尔联合阿托伐他汀对老年急性脑梗死患者血脂及颈动脉粥样硬化的影响  

Effects of Alprostadil and Atorvastatin on Blood Lipid and Carotid Atherosclerosis in Elderly Patients with Acute Cerebral Infarction

作　　者：李花[1] 许济 LI Hua;XU Ji(Department of Neurology,3201 Hospital Affiliated to Medical College,Xi'an Jiaotong University,Hanzhong,Shaanxi 723000,China;Department of Rehabilitation,3201 Hospital Affiliated to Medical College,Xi'an Jiaotong University,Hanzhong,Shaanxi 723000,China)

机构地区：[1]西安交通大学医学院附属三二〇一医院神经内科,陕西汉中723000 [2]西安交通大学医学院附属三二〇一医院康复医学科,陕西汉中723000

出　　处：《解放军医药杂志》2020年第6期42-45,50,共5页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：陕西省自然科学基础研究计划项目(2016JM1749)。

摘　　要：目的探讨前列地尔联合阿托伐他汀对老年急性脑梗死患者血脂及颈动脉粥样硬化的影响。方法将2018年1月—2019年12月收治的120例老年急性脑梗死患者分为观察组和对照组,每组60例。对照组给予阿托伐他汀睡前口服,观察组在对照组基础上联合前列地尔静脉注射,疗程均为2周。比较2组治疗前后的美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、超敏C反应蛋白(hs-CRP)、血脂、颈总动脉内膜-中层厚度(IMT)、斑块总积分、斑块面积及肾功能指标的变化。结果治疗后,2组NIHSS评分、mRS评分、hs-CRP、血脂、IMT、斑块总积分、斑块面积及肾功能指标较治疗前均得到显著改善,且观察组上述指标显著低于对照组(P<0.05)。2组均未发生明显不良反应。结论对老年急性脑梗死患者采用前列地尔联合阿托伐他汀治疗,可减轻机体炎症,改善血脂水平、斑块性质及神经功能缺损程度,提高微循环血管通透性,并发挥一定肾脏保护作用,且安全性佳。Objective To explore the effects of Alprostadil and Atorvastatin on blood lipid and carotid atherosclerosis in elderly patients with acute cerebral infarction(ACI).Methods A total of 120 elderly patients with ACI admitted between January 2018 and December 2019 were divided into the observation group and the control group,with 60 cases in each group.The control group was given Atorvastatin orally before sleep,and the observation group was given intravenous injection of Alprostadil on the basis of the control group.The treatment course was 2 weeks.Changes in the National Institutes of Health Stroke Scale(NIHSS)scores,modified Rankin Scale(mRS)scores,high-sensitivity C-reactive protein(hs-CRP),blood lipid,common carotid intima-media thickness(IMT),total plaque scores,plaque area and renal function indicators were compared between the two groups before and after treatment.Results After treatment,the NIHSS score,mRS score,hs-CRP,blood lipids,IMT,total plaque score,plaque area and renal function indexes of the two groups were significantly improved compared with those before treatment,and the above indexes of the observation group were significantly lower than those in the control group(P<0.05).No obvious adverse reactions occurred in either group.Conclusion In the treatment of elderly patients with ACI,Alprostadil and Atorvastatin can relieve inflammation in the body,improve blood lipid levels,plaque properties and the degree of neurological deficits.It also can improve microcirculation and vascular permeability,with certain renal protective effect and good safety.

关 键 词：前列地尔 阿托伐他汀 脑梗死 老年人 动脉粥样硬化 血尿素氮 甘油三酯 

分 类 号：R743.33[医药卫生—神经病学与精神病学]