小型猪创面修复模型在组织工程真皮体内验证中的应用  

Application of Mini-Pigs Wound-Repairing Model in the Validation of Tissue-engineered Dermis in vivo

作　　者：陈斯文[1] 李思放 陈雅南 祁少海[3] 陈蕾[3] Chen Si-wen;Li Si-fang;Chen Ya-nan;Qi Shao-hai;Chen Lei(Depatment of Spine surgery,the First Afiliated Hospital,Sur Yat-sen University,Guangdong Guangzhou 510080;Department of Clinical Medicine,Zhongshan School of Medicine,Sun Yal-sen University,Guangdong Guangzhou 510080;Department of Burns,the First Afliated Hospital,Sun Ya-sen University,Guangdong Guangzhou 510080)

机构地区：[1]中山大学附属第一医院脊柱外科,广东广州510080 [2]中山大学中山医学院临床医学系,广东广州510080 [3]中山大学附属第一医院烧伤外科,广东广州510080

出　　处：《江西化工》2020年第2期49-53,共5页Jiangxi Chemical Industry

基　　金：广州市科技计划产学研协同创新重大专项(201704020165);广东省自然科学基金资助项目(2020B1515020049).

摘　　要：累及真皮的皮肤损伤修复后容易形成瘢痕.如何快速、高质量的修补真皮缺损是解决上述问题的根本途径,亦是组织工程学研究的重点.猪在生理学、疾病发展等方面与人的相似度较高,是组织工程真皮的验证研究的理想动物模型.本文从实验猪的选择,组织工程真皮体内验证模型的构建,以及创面愈合质量评估等方面进行综述,为组织工程真皮的研发及临床转化提供参考.Skin lesions involving the dermis are prone to scarring after repair. Repairing dermal defects rapidly and efficiently is the essential approach to solving the issue above,which is also the focus of tissue-engineering research. Pigs are similar to human beings in physiology and pathophysiology,so they are ideal animal models for the validation study of tissue-engineered dermis. This paper reviews the selection of experimental pigs,the construction of in vivo validation model of tissue-engineered dermis and the evaluation of wound healing,which could provide reference for the research and clinical application of tissue-engineered dermis.

关 键 词：动物模型 实验猪 皮肤愈合 

分 类 号：R-332[医药卫生] R641