Oxidative stress, nutritional antioxidants and beyond  

作　　者：Qiuping Guo Fengna Li Yehui Duan Chaoyue Wen Wenlong Wang Lingyu Zhang Ruilin Huang Yulong Yin 

机构地区：[1]Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Key Laboratory of Agro-ecological Processes in Subtropical Region,Hunan Provincial Engineering Research Center for Healthy Livestock and Poultry Production,Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central,Ministry of Agriculture,Changsha 410125,China [2]University of Chinese Academy of Sciences,Beiing 100039,China [3]Hunan Co-Innovation Center of Animal Production Safety,Hunan Collaborative Innovation Center for Utilization of Botanical Functional Ingredients,Changsha 410128,China [4]Laboratory of Animal Nutrition and Human Health,School of Biology,Hunan Normal University,Changsha 410018,China

出　　处：《Science China(Life Sciences)》2020年第6期866-874,共9页中国科学（生命科学英文版）

基　　金：the National Key Research and Development Program (2016YFD0501204, 2018YFD0500405);the Youth Innovation Promotion Association CAS (2016326);the Science and Technology Projects of Hunan Province (2016SK3022, 2017RS3058);Key Project of Research and Development Plan of Hunan Province (2016NK2170);Science and Technology Projects of Changsha City (kq1801059);Youth Innovation Team Project of ISA, CAS (2017QNCXTD_ZCS);the Key Research Program of the Chinese Academy of Sciences (KFZD-SW-219);the Earmarked Fund for China Agriculture Research System (CARS-35)。

摘　　要：Free radical-induced oxidative stress contributes to the development of metabolic syndromes(Mets), including overweight,hyperglycemia, insulin resistance and pro-inflammatory state. Most free radicals are generated from the mitochondrial electron transport chain;under physiological conditions, their levels are maintained by efficient antioxidant systems. A variety of transcription factors have been identified and characterized that control gene expression in response to oxidative stress status.Natural antioxidant compounds have been largely studied for their strong antioxidant capacities. This review discusses the recent progress in oxidative stress and mitochondrial dysfunction in Mets and highlights the anti-Mets, anti-oxidative, and antiinflammatory effect of polyphenols as potential nutritional therapy.

关 键 词：reactive oxygen species oxidative stress mitochondrial dysfunction signal transduction nutritional antioxidant POLYPHENOLS 

分 类 号：R363[医药卫生—病理学]