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作 者:Lihui Lu Ruiyu Wang Minmin Luo
机构地区:[1]School of Life Sciences,Tsinghua University,Beijing 10084,China [2]Tsinghua-Peking Center for Life Sciences,Tsinghua University,Bejing 100084,China [3]National Institute of Biological Sciences(NIBS),Beijing 102206,China [4]School of Life Sciences,Peking University,Bejing 100871,China [5]Peking University-Tsinghua University-NIBS Joint Graduate Program,Bejing 102206,China [6]Chinese Institute for Brain Research,Beiing 102206,China [7]Tsinghua Institute of Multidisciplinary Biomedical Research(TIMBR),Beijing 102206,China
出 处:《Science China(Life Sciences)》2020年第6期875-885,共11页中国科学(生命科学英文版)
基 金:Ministry of Science and Technology of China (2015BAI08B02);the National Natural Science Foundation of China (91432114 and 91632302);the Beijing Municipal Government。
摘 要:Brain-to-brain interfaces(BtBIs) hold exciting potentials for direct communication between individual brains. However,technical challenges often limit their performance in rapid information transfer. Here, we demonstrate an optical brain-to-brain interface that transmits information regarding locomotor speed from one mouse to another and allows precise, real-time control of locomotion across animals with high information transfer rate. We found that the activity of the genetically identified neuromedin B(NMB) neurons within the nucleus incertus(NI) precisely predicts and critically controls locomotor speed. By optically recording Ca2+ signals from the NI of a "Master" mouse and converting them to patterned optogenetic stimulations of the NI of an "Avatar" mouse, the Bt BI directed the Avatar mice to closely mimic the locomotion of their Masters with information transfer rate about two orders of magnitude higher than previous Bt BIs. These results thus provide proof-of-concept that optical Bt BIs can rapidly transmit neural information and control dynamic behaviors across individuals.
关 键 词:brain-to-brain interface locomotion nucleus incertus fiber photometry OPTOGENETICS support vector machine(SVM)classifier
分 类 号:R318[医药卫生—生物医学工程]
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