MSCT灌注成像与肝硬化临床分级相关性分析  

Correlation between MSCT perfusion imaging and the clinical classification of hepatic cirrhosis

作　　者：周艳玲[1] 王强[2] 杨正广 李彩英[3] ZHOU Yanling;WANG Qiang;YANG Zhengguang(The First Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050011,China;不详)

机构地区：[1]河北省石家庄市第一医院,050011 [2]石家庄平安医院 [3]河北医科大学第二医院医学影像科,石家庄市050000

出　　处：《河北医药》2020年第12期1839-1841,1845,共4页Hebei Medical Journal

摘　　要：目的通过MSCT灌注扫描肝硬化患者肝脏血流灌注参数,研究不同分级肝硬化时肝脏血流变化规律。方法47例肝硬化患者和30例正常对照者采用MSCT行灌注扫描,测量并对比血流量(blood flow,BF)、血容量(blood volume,BV)、平均通过时间(mean transit time,MTT)、毛细血管表面通透性(permeability-surface,PS)、肝动脉灌注分数(hepatic arterial fraction,HAF)、IRF到达时间(IRF time of arrival,IRF-TO)等灌注参数,采用统计学分析这些参数在肝硬化患者及对照组间的变化规律。结果与正常对照组比较,随着肝硬化程度的加重肝脏的灌注参数BF、BV、MTT及IRF-TO较正常对照组逐渐降低,BF、BV、MTT及IRF-TO定量值Child A组分别为(165.89±11.69)ml·min-1·ml-1、(29.08±2.48)ml/g、(7.95±2.36)s、(4.27±0.87)s;Child B组:(138.01±11.08)ml·min-1·ml-1、(18.12±2.98)ml/g、(6.91±1.18)s、(2.78±0.61)s;Child C组:(111.04±15.64)ml·min-1·ml-1、(12.87±2.10)ml/g、(6.29±1.22)s、(1.85±0.60)s。PS和HAF值较正常对照组逐渐增高,值分别为Child A组:(28.42±5.82)ml·100 mg-1·min-1、(0.24±0.05);Child B组:(32.44±6.45)ml·100 mg-1·min-1、(0.39±0.13);Child C组:(41.93±7.12)ml·100 mg-1·min-1、(0.54±0.07)。结论MSCT灌注成像血流参数能够定量评价肝硬化严重程度,具有非常重要的临床应用价值。Objective To investigate the changes of liver hemodynamic indexes in different Child-pugh grading of patients with hepatic cirrhosis by MSCT liver perfusion.Methods A total of 47 patients with hepatic cirrhosis patients[25 males,22 females,mean age(53.79±13.56)years](observation group)and 30 healthy subjects[18 males,12 females,mean age(50.13±15.62)years](control group)were enrolled in the study.MSCT perfusion was performed in both groups.The blood flow(BF),blood volume(BV),mean transit time(MTT),permeability-surface(PS),hepatic arterial fraction(HAF),IRF time of arrival(IRF-TO)were observed and compared between the two groups.Moreover the correlation between these MSCT perfusion parameters and severity of hepatic cirrhosis was analyzed.Results With the aggravation of hepatic cirrhosis degree,the BF,BV,MTT and IRF-TO in observation group were gradually decreased,however,the levels of PS和HAF were gradually increased,as compared with those in control group.Conclusion MSCT perfusion imaging is valuable in evaluating the severity of hepatic cirrhosis,which has important clinical application value.

关 键 词：肝硬化 MSCT灌注成像 CHILD-PUGH分级 灌注参数 血流量 血容量 

分 类 号：R575.2[医药卫生—消化系统]