新疆维吾尔自治区和田地区长寿相关GWAS及其与健康状况的关系  

Genome-wide Association Study and Its Correlation with Health Status of Longevity in Hotan Area

作　　者：晋静静 陈凤辉[1] 古再努尔·阿迪力 程祖亨[1] 邱长春[1] 玛依拉·吾甫尔[1] Jin Jingjing;Chen Fenghui;Guzainuer·Adili(Department of Comprehensive Cardiology,The First Affiliated Hospital of Xinjiang Medical University,Xinjiang 830054,China)

机构地区：[1]新疆医科大学第一附属医院综合心脏内科,乌鲁木齐830054

出　　处：《医学研究杂志》2020年第6期24-28,共5页Journal of Medical Research

基　　金：国家自然科学基金资助项目(31160215);新疆维吾尔自治区创新环境专项-自然科学计划联合基金资助项目(2020D01C186)。

摘　　要：目的新疆维吾尔自治区和田地区长寿相关单核苷酸多态性(SNP)的全基因组关联分析(GWAS)及其与健康状况相关性探究。方法纳入新疆维吾尔自治区和田地区长寿人群122例为长寿组,该地区同期非长寿人群98例为对照组,采用GWAS分析与长寿相关的SNP,同时测量研究对象的体重指数(BMI)、空腹血糖(FBG)水平、收缩压(SBP)和舒张压(DBP)以及测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)以及高密度脂蛋白胆固醇(HDL-C)等血脂水平,此外采用多重回归分析长寿相关基因与健康状况的相关性。结果rs4449651 TT基因型、rs1718307 TT基因型、rs4316818 TT基因型及rs2834384 GG型与长寿呈强相关性(P<0.05)。同时长寿组人群BMI、FBG、TG、TG以及LDL-C水平降低,HDL-C水平显著升高(P<0.05)。多重线性回归分析发现BMI和rs4449651、rs1718307、rs4316818以及rs2834384均具有显著相关性(P<0.05),FBG水平与rs4449651及rs1718307呈相关性(P<0.05),TC水平则与rs1718307、rs4316818以及rs2834384呈相关性(P<0.05),TG水平与rs2834384呈相关性(P<0.05),而HDL-C以及LDL-C则与rs4316818以及rs2834384呈相关性(P<0.05)。结论rs4449651、rs1718307、rs4316818及rs2834384共4个基因型与长寿呈强相关性,同时与BMI、血糖以及血脂等健康指标具有相关性。Objective To explore single nucleotide polymorphism(SNP)by genome-wide association study(GWAS)and its correlation with health status of longevity in Hotan area.Methods Totally 122 longevity people in Hotan area were divided into the longevity group while 98 control people were divided into the control group.SNP related with longevity were analyzed by GWAS.And Body mass index(BMI),fasting blood glucose(FBG),systolic blood pressure(SBP)and diastolic blood pressure(DBP),and serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C)were measured.Moreover,multiple regression was used to analyze the correlation between longevity genes and health status.Results The rs4449651 TT genotype,rs1718307 TT genotype,rs4316818 TT genotype and rs2834384 GG genotype were strongly correlated with longevity(P<0.05).Meanwhile,the levels of BMI,FBG,TG,TG and LDL-C in the longevity group were decreased,while the levels of HDL-C were significantly increased(P<0.05).Multiple linear regression analysis showed that BMI was significantly correlated with rs4449651,rs1718307,rs4316818 and rs2834384(P<0.05).FBG level was correlated with rs4449651 and rs1718307(P<0.05).TC level was correlated with rs1718307,rs4316818 and rs2834384(P<0.05).HDL-C and LDL-C were correlated with rs4316818 and rs2834384(P<0.05).Conclusion Four genotypes of rs4449651,rs1718307,rs4316818 and rs2834384 were strongly correlated with longevity,as well as health indicators such as BMI,blood glucose and blood lipid.

关 键 词：长寿 全基因组关联分析 单核苷酸多态性 健康状况 

分 类 号：Q789[生物学—分子生物学]