Angiosarcomatous component in gliosarcoma: case report and consideration of diagnostic challenge and hemorrhagic propensity  

作　　者：Nancy Jiang Ramiro Larrazabal Waleed Alsunbul Jian-Qiang Lu 

机构地区：[1]Department of Radiology,McMaster University/Hamilton Health Sciences,Hamilton,Ontario L8L 2X2,Canada [2]Department of Surgery/Neurosurgery,McMaster University/Hamilton Health Sciences,Hamilton,Ontario L8L 2X2,Canada [3]Department of Pathology and Molecular Medicine/Neuropathology,McMaster University/Hamilton Health Sciences,Hamilton,Ontario L8L 2X2,Canada

出　　处：《The Journal of Biomedical Research》2020年第2期143-148,共6页生物医学研究杂志（英文版）

摘　　要：An angiosarcomatous component in gliosarcoma may be associated with an increased intraoperative hemorrhagic risk and preoperative diagnostic challenge. We report a unique case of gliosarcoma with an angiosarcomatous component in a 61-year-old man. His brain MRI demonstrated a well-demarcated right occipital tumor with multiple flow voids and rim-like enhancement as well as intratumoral strip and nodular enhancements. He underwent a craniotomy for tumor resection. Intraoperatively, significant tumor hemorrhage required greater efforts to control intraoperative bleeding and to maintain hemostasis. Pathological examination of the tumor revealed alternating gliomatous and sarcomatous/angiosarcomatous components with intratumoral hemorrhage. He was postoperatively treated with chemoradiation. The tumor recurred at 9 months, for which the second resection was performed with similarly greater efforts to achieve hemostasis. The recurrent tumor was pathologically similar despite treatment-associated changes. Awareness of this angiosarcomatous component in gliosarcoma with the hemorrhagic risk is important for both the preoperative diagnosis and surgical management.

关 键 词：GLIOSARCOMA glioblastoma variant angiosarcomatous component VASCULARITY hemorrhage risk 

分 类 号：R739.7[医药卫生—肿瘤]