血清CEA、CA125、CA153联合检测在可手术乳腺癌患者中的应用价值  

Application value of serum CEA,CA153,CA125 combined detection in the operable breast cancer patients

作　　者：李巍 叶国麟[1] LI Wei;YE Guolin(The First People′s Hospital of Foshan,Foshan,Guangdong 528000,China)

机构地区：[1]佛山市第一人民医院,广东佛山528000

出　　处：《现代医药卫生》2020年第12期1792-1794,共3页Journal of Modern Medicine & Health

基　　金：广东省卫生厅医学科学技术研究基金项目(WSTJJ20111123530102196806261111)。

摘　　要：目的探讨联合检测血清癌胚抗原(CEA)、糖类抗原153(CA153)和CA125在可手术乳腺癌患者中的应用价值。方法回顾性收集可手术乳腺癌患者治疗前的CEA、CA153和CA125水平,一般资料,病理类型,分期等,并使用SPSS13.0进行比较分析。结果纳入2015年1-12月该院确诊为可手术乳腺癌患者269例,CEA、CA153和CA125的平均水平分别为(2.20±2.63)μg/L、(13.40±8.04)U/mL和(14.60±9.81)U/mL;CEA、CA153和CA125的单项检测敏感度分别为6.84%、1.49%、3.54%,3项联合检测的敏感度为9.33%。结论3种肿瘤标志物单独检测对可手术乳腺癌诊断的敏感度均不高,虽然3种指标联合检测可以略微提高诊断的敏感度,但乳腺癌诊断的理想肿瘤标志物仍需进一步探索。Objective To evaluate the application value of serum carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153),CA125 combined detection in the operable breast cancer patients.Methods The CEA,CA153 and CA125 levels,general data,pathological types and stages of patients with operable breast cancer before treatment were retrospectively collected.SPSS 13.0 was used for comparative analysis.Results There were 269 cases of operable breast cancer diagnosed in the hospital from January to December 2015.The average levels of CEA,CA153 and CA125 were(2.20±2.63)μg/L,(13.40±8.04)U/mL,(14.60±9.81)U/mL,respectively.The sensitivity of CEA,CA153 and CA125 were 6.84%,1.49%and 3.54%,respectively,and the sensitivity of three tumor markers combined detection was 9.33%.Conclusion The sensitivity of three tumor markers to operable breast cancer are not high,although the sensitivity of diagnosis can be slightly improved by combined detection of three tumor markers,but ideal tumor markers for operable breast cancer diagnosis still need further exploration.

关 键 词：乳腺肿瘤 癌胚抗原 血清糖类抗原153 血清糖类抗原125 

分 类 号：R737.9[医药卫生—肿瘤]