丙戊酸钠与咪达唑仑治疗小儿癫痫持续状态的效果及安全性分析  

The Effect and Safety Analysis of Sodium Valproate and Midazolam in the Treatment of Children with Epilepsy

作　　者：王松 WANG Song(Liaoning Jinzhou Women and Infants Hospital,Jinzhou 121000,China)

机构地区：[1]辽宁省锦州市妇婴医院,辽宁锦州121000

出　　处：《中国医药指南》2020年第18期116-117,共2页Guide of China Medicine

摘　　要：目的分析采用丙戊酸钠和咪达唑仑对小儿癫痫持续状态进行治疗的临床效果,同时分析治疗的安全性。方法本文选择我院在2018年6月至2019年1月收治的82例小儿癫痫持续状态患儿作为研究对象,采用随机方法将所有患儿分为常规治疗组和联合治疗组,每组平均为41例。对两组患儿配合基础治疗,在此基础之上对常规治疗组的患儿选择采用咪达唑仑进行治疗,联合治疗组的患儿选择采用咪达唑仑联合丙戊酸钠进行治疗,对两组患儿经过不同治疗以后的效果进行评价并作出比较。结果经过治疗以后,对于本研究两组患儿的临床治疗,有效率进行比较,本研究常规治疗组的治疗总有效率为65.85%(27/41),联合治疗组的治疗总有效率为90.24%(37/41),两组患儿进行比较,P<0.05,存在明显差异,具有统计学意义;对于本研究两组患儿的治疗不良反应发生率进行比较,研究常规治疗组不良反应发生率为7.32%(3/41),联合治疗组的不良反应发生率为9.76%(4/41),两组进行比较,P>0.05,差异不具有统计学意义。结论临床选择采用丙戊酸钠联合咪达唑仑对小儿癫痫持续状态进行治疗能够取得良好的治疗效果,同时不会产生严重的不良反应,所以属于有效的治疗方案,值得推广应用。Objective To analyze the clinical effect of sodium valproate and midazolam in the treatment of pediatric patients with epilepsy,and to analyze the safety of the treatment.Methods In this study,82 pediatric patients with psia admitted to our hospital from June 2018 to January 2019 were selected as subjects.All the children were randomly divided into the conventional treatment group and the combined treatment group,with an average of 41 cases in each group.The two groups of children with basic treatment,on the basis of the conventional treatment group of children with midazolam for treatment,combined treatment group of children with sodium valproate for treatment of midazolam,the two groups of children after different treatment effect was evaluated and compared.Results After treatment,the clinical treatment and effective rate of the two groups were compared.In this study,the total effective rate of the conventional treatment group was 65.85%(27/41),and the total effective rate of the combined treatment group was 90.24%(37/41).In this study,the incidence of adverse reactions in the treatment of two groups of children was compared,the incidence of adverse reactions in the conventional treatment group was 7.32%(3/41),and the incidence of adverse reactions in the combined treatment group was 9.76%(4/41).The difference between the two groups was not statistically significant(P>0.05).Conclusion The combination of sodium valproate and midazolam for the treatment of children with epileptic status can achieve good therapeutic effect without serious adverse reactions,so it is an effective treatment scheme and worthy of promotion and application.

关 键 词：丙戊酸钠 咪达唑仑 小儿癫痫持续状态 

分 类 号：R742.1[医药卫生—神经病学与精神病学]