双酚A替代品与双酚A对非洲爪蛙急性毒性及其应激响应的比较  

Comparison on Acute Toxicity and Stress Induction of Bisphenol A with Its Substitutes to Xenopus laevis

作　　者：牛玥 朱敏 刘芃岩[2] 秦占芬[1,3] Niu Yue;Zhu Min;Liu Pengyan;Qin Zhanfen(State Key Laboratory of Environmental Chemistry and Ecological Toxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China;School of Chemistry and Environmental Sciences,Hebei University,Baoding 071002,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室,北京100085 [2]河北大学化学与环境科学学院,保定071002 [3]中国科学院大学,北京100049

出　　处：《生态毒理学报》2020年第2期141-148,共8页Asian Journal of Ecotoxicology

基　　金：国家重点研发计划资助项目(2017YFF0211203);国家自然科学基金面上项目(21876196)。

摘　　要：双酚F(bisphenol F, BPF)和双酚AF(bisphenol AF, BPAF)作为双酚A(bisphenol A, BPA)的替代品已被投入生产和使用,然而目前有关BPA替代品毒性的数据还很缺乏。本文从急性毒性和应激响应2个方面比较了BPF、BPAF与BPA对非洲爪蛙蝌蚪的毒性。结果表明,48 h的半致死浓度(LC50)顺序为BPF(11.01 mg·L^-1)>BPA(7.54 mg·L^-1)>BPAF(2.87 mg·L^-1);对氧化应激水平的影响BPAF强于BPA,BPF与BPA相近;BPA和BPAF对热休克蛋白基因表达水平有影响,BPF没有影响。本研究提示,BPAF作为BPA的替代品,其毒性强于BPA,而BPF与BPA类似。Bisphenol F(BPF)and bisphenol AF(BPAF)have been used as bisphenol A(BPA)substitutes,but little is known about their toxic effects.In this study,we compared acute toxicity and stress induction between BPF/BPAF and BPA in Xenopus laevis tadpoles.It is found that 48 h-LC50 values of BPA and its substitutes were BPF(11.01 mg·L^-1)>BPA(7.54 mg·L^-1)>BPAF(2.87 mg·L^-1).The oxidative stress induction of BPAF on X.laevis tadpoles was stronger than that of BPA and BPF.In addition,BPA has more remarkable effects on the expres-sion of heat shock protein gene than BPF,and BPAF has little ffects.Our study indicates that BPA is less harmful than BPAF,and is close to BPA.

关 键 词：双酚A 双酚F 双酚AF 非洲爪蛙 急性毒性 氧化应激 热休克蛋白 

分 类 号：X171.5[环境科学与工程—环境科学]