A case report of double-protein expression in primary uterine cervical diffuse large B cell lymphoma and a review of the literature  

作　　者：Xiaoying Quan Zhihui Zhang 

机构地区：[1]Department of Medical Oncology,the Sixth People's Hospital of Chengdu,Chengdu 610051,China [2]Department of Lymphoma,Sichuan Cancer Hospital and Research Institute,Chengdu 610041,China

出　　处：《Oncology and Translational Medicine》2020年第3期131-133,共3页肿瘤学与转化医学（英文版）

摘　　要：Primary non-Hodgkin’s lymphoma of the uterine cervix is rarely observed.Here,we report a case of"double-protein"expression in a primary uterine cervical diffuse large B-cell lymphoma that was detected based on cervical biopsies at Sichuan Cancer Hospital in December 2016 in a 53-year-old woman with a 1-month history of postmenopausal vaginal bleeding.She was diagnosed with stage IVA cervical cancer after workup and treated with six cycles of rituximab+cyclophosphamide+epirubicin+vindesine+prednisone.She showed a positive partial response after two cycles;however,response assessment revealed a progressive disease after six cycles.Based on the current condition,a treatment regimen comprising a combination of second-line chemotherapy and radiotherapy was advised for the patient.Unfortunately,she discontinued her treatment because of various factors.We conclude that"double-protein"expression in primary uterine cervical diffuse large B-cell lymphoma is difficult to treat and has a poor prognosis.Therefore,improving the diagnosis and treatment of this disease should be considered.

关 键 词：diffuse large B-cell lymphoma uterine cervix “double-protein”expression 

分 类 号：R737.33[医药卫生—肿瘤]