1022例慢性乙型肝炎病毒感染者现状及影响因素  

The current situation and influencing factors of chronic hepatitis B virus infection

作　　者：王贵菊[1] 鲁荣华[1] WANG Gui-ju;LU Rong-hua(Department of Infectious Diseases,Central People's Hospital of Tengzhou,Tengzhou Shandong 211599,China)

机构地区：[1]滕州市中心人民医院传染科,山东滕州277599

出　　处：《中国卫生工程学》2020年第3期336-338,共3页Chinese Journal of Public Health Engineering

基　　金：滕州市2017年科学技术发展计划项目[2017049]。

摘　　要：目的探讨1 022例慢性乙型肝炎病毒感染者现状及影响因素。方法以2018年4月至2019年10月间在本院住院治疗的1 022例患者为调查对象。测定乙型肝炎病毒血清标志物、肝功能、甲胎蛋白水平,同时进行肝影像学检查;将肝硬化失代偿期和原发性肝癌患者纳入不良结局组,肝炎和肝硬化代偿期患者纳入对照组。对检查结果进行综合分析。结果调查的1 022例患者中HBsAg阳性率为18.00%,各年龄段HBsAg阳性率比较差异有统计学意义(P<0.01)。141例患者中不良结局组34例,对照组107例。不良结局组中男性、年龄≥50岁的患者比例均明显高于对照组,差异均有统计学意义(均P<0.05);患者母亲HBsAg阳性情况、对乙肝了解情况、饮酒情况、生活习惯、规律治疗在不良结局组与对照组患者间比较差异均有统计学意义(均P<0.01)。多因素Logistic回归分析显示,年龄≥50岁、患者母亲HBsAg阳性、对乙肝不了解、饮酒、未规律治疗是慢性乙型肝炎患者不良结局的独立危险因素(均P<0.05)。结论本地区慢性乙型肝炎病毒感染率较高,应加强对合并危险因素患者的预防干预,降低肝硬化和肝癌的发生率。Objective To explore the current situation and influencing factors of chronic hepatitis B virus infection.Methods 1022 patients in our hospital from April 2018 to October 2019 were investigated.Serum markers,liver function and AFP levels of hepatitis B virus were measured,and liver imaging was performed.Results In 1022 cases investigated,the positive rate of HBsAg was 18.00%,and there was statistically significant difference in the positive rate of HBsAg in all age groups(P<0.01);the proportion of male patients in the adverse outcome group and patients aged≥50 years old in the adverse outcome group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05);The difference of the positive situation of HBsAg in the mother of the patient,the understanding of hepatitis B,the drinking situation,the living habits and the regular treatment between the adverse outcome group and the control group was statistically significant(P<0.01).Age≥50 years old,HBsAg positive mother,ignorance of hepatitis B,drinking and irregular treatment were independent risk factors for adverse outcomes.Conclusion The rate of chronic hepatitis B virus infection is high in this area.It should strengthen the prevention and intervention of patients with risk factors,and reduce the incidence of liver cirrhosis and liver cancer.

关 键 词：乙型肝炎 肝硬化 肝癌 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]