胃癌化疗期间给予结构脂肪乳对改善患者生活质量及疗效和不良反应的影响  

Curative effect and adverse reactions of treatment of structured triglyceride combined with chemotherapy in gastric cancer

作　　者：付蕾 李潜 闫文锋 樊素峰 钱晓燕 卢创新 仓顺东 FU Lei;LI Qian;YAN Wen-feng;FAN Su-feng;QIAN Xiao-yan;LU Chuang-xin;CANG Shun-dong(Henan Provincial People’s Hospital,Zhengzhou 450003,China;不详)

机构地区：[1]河南省人民医院,郑州大学人民医院肿瘤内科,郑州450003 [2]河南省肿瘤医院,郑州大学附属肿瘤医院内科,郑州450008 [3]河南省人民医院,郑州大学人民医院胃肠外科,郑州450003

出　　处：《医药论坛杂志》2020年第5期20-24,共5页Journal of Medical Forum

基　　金：2017年度河南省医学科技攻关计划项目(201702166)。

摘　　要：目的评价胃癌患者化疗期间加入结构脂肪乳治疗对改善患者生活质量、疗效及不良反应的影响。方法选取2018年1月—2018年12月河南省人民医院收治的80例初治局部晚期不可手术或晚期转移性胃癌患者,随机分为试验组(40例)和对照组(40例),对照组采用胃癌一线化疗方案,试验组化疗同时加入结构脂肪乳治疗。观察两组患者主观整体评估(patient-generated subjective globe assessment,PG-SGA)、生活质量(quality of life,QOL)、体重、白蛋白、前白蛋白的变化及化疗有效率、无进展生存期和治疗相关不良反应。结果试验组和对照组PG-SGA治疗后均较前明显下降,QOL、白蛋白、前白蛋白治疗后均较前明显上升,试验组治疗后体重较前明显上升,而对照组较前下降,差异均有统计学意义(P<0.05)。试验组治疗后PG-SGA下降数值更明显,试验组QOL、体重、白蛋白、前白蛋白升高的数值更明显,差异均有统计学意义(P<0.05)。试验组和对照组骨髓抑制及消化道不良反应发生率无统计学意义(P<0.05),但试验组不良反应的程度较对照组明显减轻(P<0.05)。试验组的客观有效率(60.0%)和疾病控制率(85.0%)明显高于对照组(37.5%,75.0%)(P<0.05)。试验组PFS 8.0个月,对照组PFS 7.5个月,试验组PFS较对照组略有升高,但差异无统计学意义(P=0.103)。结论化疗联合结构脂肪乳可以改善患者的一般情况,并提高治疗有效率,耐受性良好。Objective To evaluate the curative effect and adverse reactions of treatment of structured triglyceride combined with chemotherapy in gastric cancer.Methods Totally 80 patients with locally advanced or advanced gastric cancer were randomly divided into a trial group of 40 cases and a control group of 40 cases.The control group received first-line chemotherapy for gastric cancer,while the trial group received chemotherapy plus structured triglyceride.The changes of PG-SGA,QOL,body weight,albumin and prealbumin in the two groups,as well as the effective rate of chemotherapy,progression free disease(PFS)and treatment-related adverse reactions were observed.Results The PG-SGA of the trial group and the control group were significantly decreased after treatment,the QOL,albumin,prealbumin were significantly increased after treatment,the body weight of the trial group was significantly increased after treatment,while that of the control group was significantly decreased and all of the differences had statistical significances(P<0.05).The decrease of PG-SGA and the increase of QOL,body weight,albumin and prealbumin were more obvious in the trial group after treatment,with statistically significant differences(P<0.05).The incidence of bone marrow suppression and digestive tract reaction were similar in both groups(P<0.05),but the degree of adverse reactions of the trial group were significantly less than that of the control group(P<0.05).The objective response rate and disease control rate of the trial group were significantly higher than that of the control group(P<0.05).The PFS of the trial group was 8.0 months,and that of the control group was 7.5 months.The PFS of the trial group was slightly higher than that of the control group,but the difference was not statistically significant(P=0.103).Conclusion The treatment of chemotherapy combined with structured triglyceride can improve the general condition of patients and treatment efficiency and is well tolerated.

关 键 词：胃癌 结构脂肪乳 PG-SGA 疗效 不良反应 

分 类 号：R735.2[医药卫生—肿瘤]