血清IL-1β、IL-10、MCP-1水平变化对霍奇金淋巴瘤患者早期诊断和疗效预测的价值  

The value of serum IL-1β,IL-10 and MCP-1 levels changes in early diagnosis and efficacy prediction of Hodgkin's lymphoma

作　　者：吴嫱 李文静[1] 郝苗 包莉 聂鑫[2] Wu Qiang;Li Wenjing;Hao Miao;Bao Li;Nie Xin(The Outpatient Department,West China Hospital of Sichuan University,Sichuan Chengdu 610041,China;Clinical Biochemical Laboratory of Laboratory Medicine,West China Hospital of Sichuan University,Sichuan Chengdu 610041,China)

机构地区：[1]四川大学华西医院门诊部,四川成都610041 [2]四川大学华西医院实验医学科临床生化实验室,四川成都610041

出　　处：《现代肿瘤医学》2020年第13期2310-2313,共4页Journal of Modern Oncology

基　　金：四川省科技支撑项目(编号:2017SZ0252)。

摘　　要：目的:观察血清IL-1β、IL-10、MCP-1水平变化对霍奇金淋巴瘤患者早期诊断和疗效预测的价值。方法:选取2015年1月至2018月12月我科收治的霍奇金淋巴瘤患者82例(实验组),健康志愿者60例(对照组),检测两组血清IL-1β、IL-10、MCP-1的表达情况,比较霍奇金淋巴瘤在不同分期中的血清IL-1β、IL-10、MCP-1表达水平,分析血清IL-1β、IL-10、MCP-1对霍奇金淋巴瘤早期诊断和疗效预测的价值。结果:实验组患者治疗前血清IL-1β、IL-10、MCP-1水平分别高于对照组血清IL-1β、IL-10、MCP-1水平(P<0.05)。霍奇金淋巴瘤患者Ⅳ期血清IL-1β、IL-10、MCP-1水平分别高于Ⅰ、Ⅱ、Ⅲ期患者血清IL-1β、IL-10、MCP-1水平(P<0.05)。实验组患者治疗后血清IL-1β、IL-10、MCP-1水平分别低于实验组患者治疗前血清IL-1β、IL-10、MCP-1水平(P<0.05)。ROC曲线示:血清IL-1β、IL-10、MCP-1曲线下面积分别为0.788、0.800、0.696,敏感度分别为0.771、0.825、0.743,特异度分别为0.688、0.750、0.625。联合测定曲线下面积为0.906,敏感度和特异度分别为0.886和0.875。结论:血清IL-1β、IL-10、MCP-1在霍奇金淋巴瘤患者中呈现异常高表达,血清IL-1β、IL-10、MCP-1可能参与霍奇金淋巴瘤的发生发展,可作为霍奇金淋巴瘤诊断的预测指标之一。Objective:To observe the value of serum IL-1β,IL-10 and MCP-1 levels in early diagnosis and efficacy prediction of Hodgkin's lymphoma patients.Methods:82 patients(experimental group)of Hodgkin's lymphoma admitted to our department from January 2015 to December 2018,and 60 healthy volunteers(control group)were selected.The expression of serum IL-1β,IL-10 and MCP-1 in the two groups was detected.Serum IL-1β,IL-10 and MCP-1 expression levels were compared in different stages of Hodgkin's lymphoma.The value of serum IL-1β,IL-10 and MCP-1 in the early diagnosis and efficacy prediction of Hodgkin's lymphoma was analysed.Results:The levels of serum IL-1β,IL-10 and MCP-1 before treatment in the experimental group were higher than those in the control group(P<0.05).The levels of serum IL-1β,IL-10 and MCP-1 in stage IV of Hodgkin's lymphoma patients were higher than those of serum IL-1β,IL-10 and MCP-1 in stage I,II and III of Hodgkin's lymphoma patients,respectively(P<0.05).The levels of serum IL-1β,IL-10 and MCP-1 detected by the experimental group after treatment were lower than those of the experimental group before treatment(P<0.05).The ROC curve showed that the areas under the serum IL-1β,IL-10 and MCP-1 curves were 0.788,0.800 and 0.696,respectively,and the sensitivity was 0.771,0.825 and 0.743,respectively,and the specificity was 0.688,0.750 and 0.625,respectively.The area under the combined measurement curve was 0.906,and the sensitivity and specificity were 0.886 and 0.875,respectively.Conclusion:Serum IL-1β,IL-10 and MCP-1 have abnormally high expression in patients with Hodgkin's lymphoma.Serum IL-1β,IL-10 and MCP-1 may be involved in the development of Hodgkin's lymphoma,as one of the predictors of the diagnosis of Hodgkin's lymphoma.

关 键 词：白介素-1Β 白介素-10 单核细胞趋化蛋白-1 霍奇金淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]