HIV-1 Tat蛋白对脑组织中血管内皮细胞和神经细胞氧化应激影响的研究进展  

Research progress in the effect of HIV-1 Tat protein on oxidative stress of vascular endothelial cells and nerve cells in brain tissue

作　　者：郭帅志 黄涛[2] 赵丽[1] Guo Shuaizhi;Huang Tao;Zhao Li(Department of Laboratory Science of Sanitary Microbiology,School of Public Health,Shandong University,Key Laboratory of Shandong Province During the 13th Five-year Plan,Jinan 250012,China;Shandong Center for Disease Control and Prevention,Jinan 250014,China)

机构地区：[1]山东大学公共卫生学院卫生微生物检验学系山东省"十三五"高校重点实验室,济南250012 [2]山东省疾病预防控制中心,济南250014

出　　处：《中华实验和临床病毒学杂志》2020年第2期217-220,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：HIV-1可穿过血脑屏障,感染中枢神经系统,引起一系列神经系统疾病。氧化应激(oxidative stress,OS)在不同的神经退行性疾病的发病机制中具有重要作用。当机体遭受各种有害刺激时,体内氧化系统和抗氧化系统的调控水平失衡,产生大量活性氧(reactive oxygen species,ROS),从而直接或间接导致组织损伤。HIV-1感染细胞后释放的反式转录激活因子Tat蛋白对于脑组织的损伤具有重要作用,它可诱导血管内皮细胞和神经细胞产生ROS,使机体处于慢性氧化应激状态,加重疾病的发展。本文就HIV-1 Tat蛋白对血管内皮细胞和神经细胞氧化应激影响的研究进展进行综述。HIV-1 can cross the blood-brain barrier,infect the central nervous system,and cause a series of nervous system diseases.Oxidative stress(OS)plays an important role in the pathogenesis of different neurodegenerative diseases.When the body is subjected to various harmful stimulation,the regulation level of oxidation system and antioxidant system is out of balance,producing a large number of reactive oxygen species,which directly or indirectly leads to tissue damage.Tat protein,a trans-activator of transcription released after HIV-1 infection,plays an important role in brain injury.It can induce endothelial cells and nerve cells to produce living oxygen,make the body in a state of chronic oxidative stress,and aggravate the development of the disease.In this paper,the research progress in studies on the effect of HIV-1 Tat protein on oxidative stress of vascular endothelial cells and nerve cells was reviewed.

关 键 词：HIV-1 TAT蛋白 氧化应激 血管内皮细胞 神经细胞 

分 类 号：R74[医药卫生—神经病学与精神病学]