以自主神经功能异常为首发症状的富亮氨酸胶质瘤失活1蛋白抗体相关脑炎一例  

A case report of leucine rich glioma inactivated 1-antibody encephalitis with autonomic dysfunction

作　　者：宋江曼 盛爱珍[1] 曾湘豫[1] 龚涛[1] 陈玉辉[1] Song Jiangman;Sheng Aizhen;Zeng Xiangyu;Gong Tao;Chen Yuhui(Department of Neurology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China;Department of Neurology,731 Hospital of China Aerospace Science and Industry Corporation,Beijing 100074,China)

机构地区：[1]北京医院神经内科,国家老年医学中心,100730 [2]中国航天科工集团七三一医院神经内科,北京100074

出　　处：《中华神经科杂志》2020年第5期364-367,共4页Chinese Journal of Neurology

摘　　要：富亮氨酸胶质瘤失活1蛋白(LGI1)是近年来新发现的参与自身免疫性脑炎的一种靶蛋白。LGI1抗体相关脑炎常见症状为癫痫、认知功能障碍,但少见以自主神经功能障碍起病者。报道1例以多汗、体位性低血压为首发症状的LGI1抗体相关脑炎的临床表现,并复习相关文献,分析以自主神经障碍起病的LGI1抗体相关脑炎的临床特点,以提高对该病的认识,尽早诊断及治疗,改善临床预后。Leucine rich glioma inactivated 1(LGI1)is a protein which is identified as the target involving in autoimmune encephalitis.Seizures and cognitive declines are two main symptoms of LGI1-antibody encephalitis.However,autonomic dysfunction symptoms are not prominent as seizures and cognitive defection and are easily overlooked by physicians.We reported a case with LGI1-antibody encephalitis whose onset symptoms were autonomic dysfunction including sweating,orthostatic hypotension.The features of this case was described in detail and the related literatures were reviewed in order to enhance the knowledge of the disease.

关 键 词：神经系统自身免疫疾病 脑炎 自主神经系统 富亮氨酸胶质瘤失活1蛋白 

分 类 号：R742[医药卫生—神经病学与精神病学]