睡眠时长与发生缺血性脑卒中的相关性研究:一项大型社区研究  

Correlation between sleep duration and ischemic stroke:A large community study

作　　者：马青艳[1] 闫斌 杨建 范雅娟 赵斌斌 何潇言 朱峰[3] 王崴[1] 马现仓[1] MA Qingyan;YAN Bin;YANG Jian;FAN Yajuan;ZHAO Binbin;HE Xiaoyan;ZHU Feng;WANG Wei;MA Xiancang(Department of Psychiatry,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Clinical Research Center,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Translational Medicine Center,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院精神心理卫生科,陕西西安710061 [2]西安交通大学第一附属医院临床研究中心,陕西西安710061 [3]西安交通大学第一附属医院转化医学中心,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2020年第4期593-597,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省创新人才推进计划-重点科技创新团队计划项目(No.2017KCT-20)。

摘　　要：目的根据多导睡眠监测收集的睡眠时长探讨社区人群中睡眠时长与发生缺血性脑卒中之间的关系。方法参与研究的受试者共2062例,其中男性724例,女性1338例;平均年龄为61.44岁。本研究将受试者根据睡眠时长(SD)分为3组:短睡眠时长SD<6 h、长睡眠时长SD>8 h和正常睡眠时长6 h≤SD≤8 h。采用多因素Logistic回归分析探讨不同睡眠时长与发生缺血性脑卒中之间的独立关联。结果①一般资料比较:3组在性别、年龄、BMI、糖尿病患病、血清三酰甘油水平等方面均有不同程度差异(P<0.05);②缺血性脑卒中发生率比较:SD<6 h组缺血性脑卒中的发生率明显高于SD>8 h组和6 h≤SD≤8 h组(发生率分别为5.9%、2.7%、1.6%;P=0.044、P<0.001);③Logistic回归分析:单因素Logistic回归分析提示短睡眠时长,即SD<6 h与缺血性脑卒中的发生有关(OR=3.845,95%CI:1.789~8.266,P=0.001);调整性别、年龄、婚姻状况、饮酒、高血压、糖尿病、三酰甘油等因素后,多因素Logistic回归分析结果提示SD<6 h仍是缺血性脑卒中发生的独立危险因素(OR=2.629,95%CI:1.033~6.693,P=0.043)。结论不同睡眠时长的人群,缺血性脑卒中的发生率不同。其中短睡眠时长人群缺血性脑卒中的发生率更高。Objective To investigate the relationship between sleep duration(SD)collected by polysomnography and ischemic stroke in community populations.Methods We recruited 2062 participants,including 724 males and 1338 females.The mean age of the all participants was 61.44 years.In this study,the subjects were divided into three groups according to SD:short SD(<6 h),long SD(>8 h),and normal SD(6-8 h).Logistic regression was used to analyze the independent association between the three different sleep durations and the occurrence of ischemic stroke.Results①The three groups differed significantly in gender,age,BMI,prevalence of diabetes and serum triglyceride levels(P<0.05).②The incidence of ischemic stroke was significantly higher in short SD group than in long SD group and normal SD group(the incidence rates were 5.9%,2.7%and 1.6%,respectively;P=0.044,P<0.001).③Univariate logistic regression analysis suggested that short SD was associated with the occurrence of ischemic stroke(OR=3.845,95%CI:1.789-8.266,P=0.001).After adjusting potential factors such as gender,age,marital status,alcohol consumption,hypertension,diabetes and triglycerides,multivariate logistic regression analysis showed that short SD was still an independent risk factor for ischemic stroke(OR=2.629,95%CI:1.033-6.693,P=0.043).Conclusion The incidence of ischemic stroke differs in people with different SD.Among them,the incidence of ischemic stroke is higher in people with short SD.

关 键 词：睡眠时长 缺血性脑卒中 社区人群 

分 类 号：R749.4[医药卫生—神经病学与精神病学]