老年帕金森病血清生化指标与非运动症状的关系  

Relationship between serum biochemical indexes and nonmotor symptoms in senile Parkinson's disease

作　　者：郭芬[1] 王晓雪[1] 许宏侠 刘欣欣[1] GUO Fen;WANG Xiaoxue;XU Hongxia;LIU Xinxin(The First Affiliated Hospital of Henan University,Kaifeng 475001,China)

机构地区：[1]河南大学第一附属医院,河南开封475001

出　　处：《中国实用神经疾病杂志》2020年第13期1131-1135,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省高等学校重点科研项目(编号:18B310013)。

摘　　要：目的探讨老年帕金森病(PD)患者血清生化指标与非运动症状的关系。方法对医院2017-03—2019-09收治的85例老年PD患者的临床资料进行回顾性分析,同时回顾性分析同时间段体检的79例老年健康者资料,分别为研究组、对照组。对比2组血清生化指标血清神经元特异性烯醇化酶(NSE)、神经肽Y(NPY)、酸性钙结合蛋白(S-100β)水平情况,对比2组非运动症状情况简易智力状况检查量表(MMSE)评分、韦氏记忆量表(WMS)评分、自主神经症状量表(ASP)评分、蒙特利尔认知评估量表(MoCA)评分、日常生活自理能力量表(ADL)评分,分析研究组患者血清NSE、NPY、S-100β水平与非运动症状的相关性。结果研究组血清NSE、NPY、S-100β水平均高于对照组(P<0.05);研究组MMSE评分、MQ评分、MoCA评分、ADL评分均低于对照组(P<0.05),ASP评分高于对照组(P<0.05);研究组血清NSE、NPY、S-100β均与MMSE评分、MQ评分、MoCA评分、ADL评分呈强烈负相关(P<0.05),血清NSE、NPY、S-100β均与ASP评分呈强烈正相关(P<0.05)。结论老年PD患者血清NSE、NPY、S-100β水平偏高,智力、记忆功能、自主非运动症状、认知功能、自理能力偏低,血清NSE、NPY、S-100β水平与非运动症状均有相关性。Objective To investigate the relationship between serum biochemical indexes and nonmotor symptoms in elderly patients with Parkinson's disease(PD).Methods The clinical data of 85 elderly PD patients admitted to the hospital from March 2017 to September 2019 were retrospectively analyzed.Meanwhile,the physical examination data of 79 elderly healthy people who underwent general physical examination in the hospital during the same period were retrospectively analyzed.They were recorded as study group and control group respectively.The levels of serum biochemical indexes(serum neuron-specific enolase(NSE),neuropeptide Y(NPY),acid calcium-binding protein(S-100β))in the two groups were compared.The non-motor symptoms(mini-mentalstateexamination(MMSE),Wechsler memory scale(WMS),Autonomic symptom scale(ASP),Montreal cognitive assessment scale(MoCA),activity of daily living scale(ADL))of the two groups were compared.The correlation between serum NSE,NPY,S-100βand non-motor symptoms was analyzed.Results The serum levels of NSE,NPY and S-100βin the study group were higher than those in the control group(P<0.05).MMSE,MQ,MoCA and ADL scores in the study group were lower than those in the control group(P<0.05),while ASP scores were higher than those in the control group(P<0.05).In the study group,serum NSE,NPY and S-100βwere strongly negatively correlated with MMSE,MQ,MoCA and ADL scores(P<0.05),while serum NSE,NPY and S-100βwere strongly positively correlated with ASP scores(P<0.05).Conclusion The serum levels of NSE,NPY and S-100βare higher in elderly PD patients.Intelligence,memory function,autonomic nerve function,cognitive function,self-care ability are lower,and serum levels of NSE,NPY and S-100βare correlated with non-motor symptoms.

关 键 词：帕金森病 神经元特异性烯醇化酶 神经肽Y 酸性钙结合蛋白 非运动症状 关系 

分 类 号：R745[医药卫生—神经病学与精神病学]