银杏二萜内酯葡胺注射液联合丁苯酞治疗急性脑梗死的疗效分析  

Clinical effect analysis of Ginkgo biloba diterpene lactide combined with Butylphthalide in the treatment of acute cerebral infarction

作　　者：刘君[1] 衡卫卫[1] 刘焕 张冠群[1] 王江波[1] 李君[1] LIU Jun;HENG Weiwei;LIU Huan;ZHANG Guanqun;WANG Jiangbo;LI Jun(Department of Neurology,Xuzhou Central Hospital,Xuzhou 221009,China)

机构地区：[1]徐州市中心医院神经内科,江苏徐州221009

出　　处：《中国实用神经疾病杂志》2019年第17期1900-1904,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨银杏二萜内酯葡胺联合丁苯酞治疗急性脑梗死的临床疗效。方法2017-09—2018-09徐州市中心医院收治的68例急性脑梗死患者,应用随机数字法将其分成对照组和实验组各34例。对照组仅用丁苯酞单药治疗,实验组在丁苯酞的基础上加用银杏二萜内酯葡胺,治疗后评估2组不同治疗方案的NIHSS评分、临床疗效及药物的不良反应发生率。结果2组用药前的NIHSS评分对比,差异无统计学意义(P>0.05),用药后实验组NIHSS评分为(2.87±2.27)分,显著低于对照组的(4.42±2.34)分,差异有统计学意义(P<0.05);对照组治疗效率为73.5%,实验组为94.1%,2组治疗有效率差异有统计学意义(P<0.05);对照组和实验组不良反应发生率分别为5.9%、2.9%,2组比较差异无统计学意义(P>0.05)。结论急性脑梗死时应用银杏二萜内酯葡胺联合丁苯酞治疗,较丁苯酞单药应用具有更好的临床疗效,且不良反应发生率也未见明显增加。Objective To analyze the clinical effects of Ginkgo biloba diterpene lactone and Butylphthalide in the treatment of acute cerebral infarction.Methods From September 2017 to September 2018,68 patients with acute cerebral infarction were randomly divided into two groupscontrol group(n=34)and experimental group(n=34).The patients in the control group were treated with Butylphthalide,on the basis of which,the patients in the experimental group were treated with Ginkgo diterpene lactone staphyloamine injection.The NIHSS score,therapeutic effect and adverse reaction were observed before and after treatment.Results The NIHSS scores of the two groups before medication were compared,and there was no significant difference(P>0.05).The NIHSS scores of the experimental group after medication were(2.87±2.27)points,significantly lower than those of the control group(4.42±2.34)points,and the difference was statistically significant(P<0.05).The treatment efficiency of the control group was 73.5%,and that of the experimental group was 94.1%.There were statistically significant differences in the efficiency between the two groups(P<0.05).The incidence of adverse reactions in the control group and the experimental group was 5.9%and 2.9%,respectively,and there was no significant difference between the two groups(P>0.05).Conclusion The combination of Ginkgo biloba diterpene lactone and Butylphthalide has significant clinical effect in the treatment of acute cerebral infarction.It can effectively improve the neurological function of the patients and is safe and worthy of clinical application.

关 键 词：急性脑梗死 银杏二萜内酯葡胺 丁苯酞 

分 类 号：R743.33[医药卫生—神经病学与精神病学]