N-甲基-D-天冬氨酸受体在长时程增强中的作用  

Role of N-methyl-D-aspartic acid receptor in long-term potentiation

作　　者：刘畅 李志强 武慧欣 张媛 木云珍 吴锡南[3] LIU Chang;LI Zhi-qiang;WU Hui-xin;ZHANG Yuan;MU Yun-zhen;WU Xi-nan(School of Public Health,Kunming Medical University,Kunming Yunnan,650500,China;Biomedical Engineering Research Center,Kunming Medical University,Kunming Yunnan,650500,China;Graduate Department,Kunming Medical University,Kunming Yunnan,650500,China)

机构地区：[1]昆明医科大学公共卫生学院,云南昆明650500 [2]昆明医科大学生物医学工程研究中心,云南昆明650500 [3]昆明医科大学研究生部,云南昆明650500

出　　处：《职业与健康》2020年第7期1000-1004,共5页Occupation and Health

基　　金：国家自然科学基金项目(81560525)。

摘　　要：突触可塑性是学习记忆的神经生物学基础,神经递质充当着信使的角色。神经递质可以分为兴奋性神经递质和抑制性神经递质,而谷氨酸是中枢神经系统中分布广,作用强的兴奋性神经递质。N-甲基-D-天冬氨酸受体(NMDARs)在学习记忆功能中发挥重要作用,主要以诱导长时程增强(LTP)的形式来调节学习和记忆过程,被称作学习记忆的开关。本文主要对NMDARs的分类、LTP现象及Ca^2+信号通道诱导机制进行综述,主要描述了NMDARs在LTP中的作用,为进一步研究提供参考。Synaptic plasticity is the neurobiological basis of learning and memory,which plays a vital role during the transmission of nerve information.Neurotransmitter includes excitatory neurotransmitter and inhibitory neurotransmitter.Glutamate,as an excitatory neurotransmitter,is widely distributed in the central nervous system.N-methyl-D-aspartate receptors(NMDARs)play an important role in learning and memory.Its main function is to induce the formation of long-term potentiation(LTP),which is also known as the switch of learning and memory.These points are reviewed in this paper including the classification of NMDARs,LTP and Ca^2+ channel induction mechanism.It is described mainly what NMDARs play role of LTP,which provide reference for further research.

关 键 词：N-甲基-D-天冬氨酸受体 学习记忆 NR1亚基 NR2亚基 NR3亚基 长时程增强 

分 类 号：R394[医药卫生—医学遗传学]