原发性食管小细胞癌48例临床分析  

Clinical Analysis of 48 Cases of Primary Esophageal Small Cell Carcinoma

作　　者：吴晗 高社干[1] WU Han;GAO She-gan(Department of Oncology,the First Affiliated Hospital,School of Clinical Medicine of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院,第一附属医院肿瘤内科,河南洛阳471003

出　　处：《食管疾病》2020年第2期141-145,共5页Journal of Esophageal Diseases

摘　　要：目的从免疫组化、生存分析、不良事件等方面,研究原发性食管小细胞癌的临床特点、治疗方法及预后状况。方法对48例原发性食管小细胞癌患者的临床资料进行回顾性分析,分析不同治疗方法的治疗效果,并对48例原发性食管小细胞癌患者肿瘤组织进行常规病理学检查及神经元特异性烯醇化酶(NSE)及嗜铬素A(CgA)免疫组织化学染色。对所有入组患者进行电话随访,记录已经死亡患者的死亡时间及死亡原因,并对尚未死亡的患者持续电话随访。采用SPSS 23.0分析患者的临床特征、治疗模式与预后之间的关系。结果37例局限期患者的中位生存时间为13.2个月,11例广泛期患者的中位生存时间为6.5个月,生存时间差异具有统计学意义(P<0.05)。48例原发性食管小细胞癌患者组织中NSE和CgA染色呈高表达。结论原发性食管小细胞癌应采用以化疗为主的综合治疗,局限期以手术联合化疗,广泛期以放疗联合化疗为主;NSE和CgA在食管小细胞癌诊断中具有一定作用;局限期的患者中位生存时间明显长于广泛期的患者。Objective The clinical characteristics,treatment and prognosis of primary esophageal small cell carcinoma were studied from the aspects of immunohistochemistry,survival analysis and adverse events.Methods The clinical data of 48 patients with primary small cell carcinoma of the esophagus were analyzed retrospectively.Their therapeutic effects of different methods were analyzed.The tumor tissues of the 48 patients with primary small cell carcinoma of the esophagus were examined by routine pathology and immunohistochemical staining of NSE and CGA.All the patients were followed up by telephone,the time and cause of death were recorded,and the patients who had not died were followed up further.SPSS 23.0 was used to analyze the relationship among clinical characteristics,treatment mode and prognosis.Results The median survival time of 37 patients with local time limit was 13.2 months,and that of 11 patients with extensive time limit was 6.5 months(P<0.05).NSE and CGA were highly expressed in 48 cases of primary esophageal small cell carcinoma.Conclusion The primary small cell carcinoma of esophagus should be treated with chemotherapy mainly.Operation combined with chemotherapy could be used in the patients with limited period,and radiotherapy combined with chemotherapy could be used in the patients with extensive period.NSE and CGA play a role in the diagnosis of small cell carcinoma of esophagus.The median survival time of the limited period is significantly longer than that of the extensive period.

关 键 词：食管小细胞癌 单纯治疗 综合治疗 生存率 回顾性研究 

分 类 号：R735.1[医药卫生—肿瘤]