持续经肝动脉灌注联合栓塞治疗胃癌肝转移的临床疗效和安全性评价  

Evaluation on the Clinical Efficacy and Safety of Transhepatic Arterial Continuous Infusion Combined with Embolization in the Treatment of Liver Metastasis of Gastric Cancer

作　　者：马洺远[1] 黄利生[2] 林纲毅[1] 刘文亚 MA Mingyuan;HUANG Lisheng;LIN Gangyi;LIU Wenya(Department of Vascular Intervention,Shantou Central Hospital,Shantou 515031,China;Department of Radiotherapy,the Affiliated Tumor Hospital of Shantou University Medical College,Shantou 515031,China)

机构地区：[1]汕头市中心医院血管介入科,广东汕头515031 [2]汕头大学医学院附属肿瘤医院放疗科,广东汕头515031

出　　处：《临床医学工程》2020年第6期765-766,共2页Clinical Medicine & Engineering

摘　　要：目的探讨持续经肝动脉灌注联合栓塞治疗胃癌肝转移的临床疗效和安全性。方法选择我院2016年9月至2018年10月收治的胃癌肝转移患者40例,随机分为两组各20例。对照组采用肝动脉栓塞治疗,观察组采用持续经肝动脉灌注联合栓塞治疗。比较两组的临床疗效及不良反应发生率;随访一年,比较两组患者的1年生存率。结果观察组的治疗总有效率为60.00%,显著高于对照组的25.00%,差异具有统计学意义(P <0.05)。观察组的不良反应发生率为50.00%,显著低于对照组的80.00%,差异具有统计学意义(P <0.05)。观察组和对照组的1年生存率分别为90.00%和75.00%,组间差异无统计学意义(P>0.05)。结论相较于单纯肝动脉栓塞,持续经肝动脉灌注联合栓塞治疗胃癌肝转移可显著提高临床疗效,降低不良反应发生率。Objective To explore the clinical efficacy and safety of transhepatic arterial continuous infusion combined with embolization in the treatment of liver metastasis of gastric cancer.Methods 40 patients with liver metastasis of gastric cancer admitted to our hospital from September 2016 to October 2018 were selected and randomly divided into two groups,with 20 cases in each group.The control group was treated with hepatic artery embolization,and the observation group was treated with transhepatic arterial continuous infusion combined with embolization.The clinical efficacy and incidence of adverse reactions were compared between the two groups.One-year follow-up was conducted to compare the 1-year survival rate between the two groups.Results The total effective rate of treatment in the observation group was 60.00%,significantly higher than 25.00%in the control group,with statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group was 50.00%,significantly lower than 80.00%in the control group,with statistically significant difference(P<0.05).The 1-year survival rates of the observation group and the control group were 90.00%and 75.00%,respectively,with no statistically significant difference between the two groups(P>0.05).Conclusions Compared with simple hepatic artery embolization,transhepatic arterial continuous infusion combined with embolization in the treatment of liver metastasis of gastric cancer can significantly improve the clinical efficacy and reduce the incidence of adverse reactions.

关 键 词：持续经肝动脉灌注 肝动脉栓塞 胃癌肝转移 

分 类 号：R73-37[医药卫生—肿瘤]