原发性膜性肾病足细胞抗原研究进展  

Research progress in podocyte antigens in primary membranous nephropathy

作　　者：李臻(综述)[1] 李贞 陈伟琴[1] 殷红梅[1] 胡晓波(审校)[1] LI Zhen;LI Zhen;CHEN Weiqin;YIN Hongmei;HU Xiaobo(Department of Clinical Laboratory,Affiliated Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China)

机构地区：[1]上海中医药大学附属龙华医院检验科,200030

出　　处：《重庆医学》2020年第12期2023-2028,共6页Chongqing medicine

基　　金：上海市卫生和计划生育委员会面上项目(201640169);上海中医药大学附属龙华医院国家中医临床研究基地龙医学者(育苗计划LYTD-66)。

摘　　要：膜性肾病是一种常见原发性肾小球肾病,是导致终末期肾脏病的主要原因之一,根据其病因是否明确可分为原发性膜性肾病和继发性膜性肾病。近年来发现了中性肽链内切酶、M型磷脂酶A2受体、1型血小板反应蛋白7A域等自身抗原和植入抗原阳离子化牛血清清蛋白,为原发性膜性肾病的发病机制提供了线索,也对临床诊断治疗起到了指导作用。现将对已发现的足细胞抗原与原发性膜性肾病的研究进展进行综述。Membranous nephropathy is a common primary glomerular nephropathy,which is one of the main causes leading to end-stage renal disease.According to the pathogeny,it can be divided into primary membranous nephropathy and secondary membranous nephropathy.In recent years,some autoantigens such as neutral peptide chain endopeptidase,M-type phospholipase A2 receptor,type 1 thrombospondin 7A domain,etc.and implanted antigen cationized bovine serum albumin not only provide the clues for the pathogenesis of membranous nephropathy,but also play the guiding role in its clinical diagnosis and treatment.This article reviews the research progress in the discovered podocyte antigens and primary membranous nephropathy.

关 键 词：原发性膜性肾病 足细胞抗原 M型磷脂酶A2受体 血小板反应蛋7A域 

分 类 号：R363[医药卫生—病理学]