前列地尔联合罂粟碱治疗缺血性肠病的疗效探讨  

Effect of alprostol combined with papaverine in the treatment of ischemic bowel disease

作　　者：李志强[1] 杜艳君[1] 张丽 王宝霞 王秀伟 彭旭涛 Li zhiqiang;Du yanjun;Zhang li;Wang baoxia;Wang xiuwei;Peng xutao(Fangshan District First Hospital,Beijing 102400;Quyang Hospital of Traditional Chinese Medicine,Baoding,Hebei Quyang 073199)

机构地区：[1]北京市房山区第一医院,北京102400 [2]河北省保定市曲阳县中医院,河北曲阳073199

出　　处：《当代医药论丛》2020年第9期8-10,共3页

基　　金：首都医学发展基金资助项目:1009-1006《北京地区急性心衰治疗现状及预后临床研究》。

摘　　要：目的:探讨用前列地尔联合罂粟碱治疗缺血性肠病的临床疗效。方法:选取2015年1月至2018年12月期间北京市房山区第一医院收治的缺血性肠病患者105例作为研究对象。将其随机分为观察组(n=53)和对照组(n=52)。在两组患者入院后,对其均进行常规治疗。在此基础上,为对照组患者采用罂粟碱进行治疗,为观察组患者采用前列地尔联合罂粟碱进行治疗。然后对比两组患者的治疗效果和不良反应的发生情况。结果:1)观察组患者治疗的总有效率高于对照组患者,治疗后其腹痛症状缓解的时间、肠功能恢复正常的时间、便潜血消失的时间、肠黏膜恢复正常的时间均短于对照组患者,P<0.05。2)治疗后,两组患者血清D-二聚体的水平均较治疗前明显下降,且观察组患者血清D-二聚体的水平低于对照组患者,P<0.05。3)两组患者不良反应的发生率相比,P>0.05。结论:用前列地尔联合罂粟碱治疗缺血性肠病可取得显著的临床疗效,且安全性较高。Objective:To investigate the clinical efficacy of alproterid combined with papaverine in the treatment of ischemic bowel disease.Methods:105 patients with ischemic enteropathy admitted to The First Hospital of Fangshan District,Beijing from January 2015 to December 2018 were selected as study subjects.They were randomly divided into observation group(n=53)and control group(n=52).After admission,both groups received routine treatment.On this basis,patients in the control group were treated with papaverine,and patients in the observation group were treated with alprostadil and papaverine.Then the treatment effect and the occurrence of adverse reactions were compared between the two groups.Results:1)The total effective rate of patients in the observation group was higher than that in the control group,and the time of relief of abdominal pain symptoms,recovery of intestinal function,loss of stool occult blood and restoration of intestinal mucosa after treatment were shorter than those in the control group(P<0.05).2)After treatment,the serum D-dimer level in both groups was significantly lower than that before treatment,and the serum D-dimer level in the observation group was lower than that in the control group(P<0.05).3)the incidence of adverse reactions between the two groups was P>0.05.Conclusion:The treatment of ischemic bowel disease with alprostadil combined with papaverine is effective and safe.

关 键 词：缺血性肠病 罂粟碱 前列地尔 

分 类 号：R574[医药卫生—消化系统]