P2X7受体在睡眠觉醒环路中发挥的作用  

The role of P2X7 receptors in the sleep‑wake cycle

作　　者：黄逸菲 钟琦[1] 张盼盼 陈畅[1] 张宗泽[1] Huang Yifei;Zhong Qi;Zhang Panpan;Chen Chang;Zhang Zongze(Department of Anesthesiology,Zhongnan Hospital,Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院麻醉科,430071

出　　处：《国际麻醉学与复苏杂志》2020年第5期527-531,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81571291,81671060,81771160)。

摘　　要：全身麻醉和睡眠在表型、脑电生理、脑功能影像以及神经网络调节机制等诸多方面均有相似的表现,但其机制尚不清楚。P2X7受体(P2X7 receptor,P2X7R)存在于睡眠觉醒环路某些神经元群体中,并影响睡眠觉醒状态,因此探讨P2X7R在全身麻醉引起意识消失发挥的作用。文章总结了P2X7R在睡眠觉醒环路中所起到的促进作用是通过Panx-ATP-P2X7R-睡眠调节物质(sleep regulatory substances,SRS)通路实现的,为未来研究P2X7R在全身麻醉引起意识消失的机制研究提供了理论基础。General anesthesia and sleeping share similar manifestations in many aspects,such as phenotype,brain electrophys⁃iology,brain functional imaging and the regulation of neural network,but the mechanism involved is still unclear.P2X7 receptor(P2X7R)exists in some groups of neurons in the sleep⁃wake loop and affects sleep⁃wake condition.Therefore,the role of P2X7R in un⁃consciousness under general anesthesia is discussed.The paper summarized that P2X7R's promoting role in the sleep⁃wake loop through the Panx⁃ATP⁃P2X7R⁃sleep regulatory substances(SRS)pathway,so as to provide theoretical evidence for future research on the mechanism of unconsciousness under general anesthesia.

关 键 词：P2X7受体 睡眠觉醒环路 麻醉 睡眠调节物质 

分 类 号：R[医药卫生]