不同剂型聚乙二醇电解质在结肠镜检查前肠道准备中的应用比较  

Comparison of different dosage forms of polyethylene glycol electrolytes in the bowel preparation before colonoscopy

作　　者：占俊[1] 汤进芝 汪文生 夏先明[1] 唐敏 ZHAN Jun;TANG Jin-zhi;WANG Wen-sheng;XIA Xian-ming;TANG Min(Department of Gastroenterology,Fourth Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230011,China)

机构地区：[1]安徽医科大学第四附属医院消化内科,安徽合肥230011

出　　处：《中华全科医学》2020年第8期1283-1286,共4页Chinese Journal of General Practice

基　　金：安徽省高校自然科学研究项目(KJ2017A185)。

摘　　要：目的比较溶液剂型和散剂型聚乙二醇电解质在结肠镜检查前肠道准备中的应用效果。方法选取2018年10月—2019年4月在安徽医科大学第四附属医院行结肠镜检查的400例患者。采用等距随机抽样方法将患者随机分至2组,A组200例,B组200例。A组使用溶液剂型聚乙二醇电解质口服溶液,B组使用散剂型复方聚乙二醇电解质散。观察比较2组患者肠道准备的清洁程度、胃肠道不适症状发生率以及患者满意度。结果溶液剂型和散剂型聚乙二醇电解质均有较好的肠道清洁效果(84.0%vs.81.5%),差异无统计学意义(χ^2=0.438,P=0.508)。2种剂型PEG引起患者恶心及腹胀的发生率较高,但散剂型恶心发生率(14.0%vs.7.5%)及腹胀发生率(11.0%vs.4.5%)均高于溶液剂型,差异有统计学意义(P<0.05),且2组患者胃肠道不适症状总发生率也是散剂型较高(27.5%vs.9.5%,χ^2=21.490,P<0.001)。A组患者满意度评分为8.96±0.56,B组患者满意度评分为8.36±0.83,A组患者满意度明显高于B组(t=8.440,P<0.001)。结论溶液剂型和散剂型聚乙二醇电解质在结肠镜检查前肠道准备中肠道清洁效果相当,但溶液剂型聚乙二醇电解质有较低的胃肠道不适症状发生率和较高的患者满意度,具有一定的临床应用优越性。Objective To compare the effect of solution-type and powder-type polyethylene glycol electrolyte in bowel preparation before colonoscopy. Methods Total 400 patients who underwent colonoscopy in the Fourth Affiliated Hospital of Anhui Medical University from October 2018 to April 2019 were selected. Patients were randomly divided into A and B groups using equidistant random sampling, 200 cases in each group. Group A was treated with solution-type polyethylene glycol electrolyte oral solution and group B with powder-type compound polyethylene glycol electrolyte powder. The cleanliness of bowel, incidence of gastrointestinal symptoms and patient satisfaction were observed. Results Both solution-type and powder-type polyethylene glycol electrolytes had good bowel cleansing effects(84.0% vs. 81.5%), and the difference was no significant(χ~2=0.438, P=0.508). Two types of polyethylene glycol caused a higher incidence of nausea and bloating. The incidence of nausea and bloating in the powder-type polyethylene glycol electrolytes were higher than those of the solution-type polyethylene glycol electrolytes(14.0% vs. 7.5% and 11.0% vs. 4.5%), the differences were statistically significant(P<0.05), and the total incidence of gastrointestinal discomfort symptoms was also higher in powder-type polyethylene glycol electrolytes(27.5% vs. 9.5%, χ~2=21.490, P<0.001). The satisfaction of group A patients(8.96±0.56) was significantly higher than that of group B(8.36±0.83), t=8.440, P<0.001. Conclusion Solution-type and powder-type polyethylene glycol electrolytes have comparable bowel cleansing performance, but solution-type polyethylene glycol electrolytes have a lower incidence of gastrointestinal discomfort and better patient satisfaction, which has better clinical application advantages.

关 键 词：肠道准备 聚乙二醇电解质 剂型 肠道清洁度 患者满意度 

分 类 号：R574.6[医药卫生—消化系统] R472.91[医药卫生—内科学]