自体富血小板血浆治疗中重度干眼的疗效性及安全性  

The efficacy and safety of autologous platelet-rich plasma in the treatment of moderate to severe dry eye disease

作　　者：邢杰[1] 贾莉 黄海东[1] 贾世英 孙喆[3] 朱文龙 杨楠 Xing Jie;Jia Li;Huang Haidong;Jia Shiying;Sun Zhe;Zhu Wenlong;Yang Nan(Department of Ophthalmology and Otorhinolaryngology,Liaoning Armed Police Corps Hospital,Shenyang 110034,China;Department of Laboratory,Liaoning Armed Police Corps Hospital,Shenyang 110034,China;Department of Medical Office,Liaoning Armed Police Corps Hospital,Shenyang 110034,China;Department of 2nd Internal Medicine,Liaoning Armed Police Corps Hospital,Shenyang 110034,China;Department of Ophthalmology,PLA 967 Hospital,Dalian 116021,China)

机构地区：[1]武警辽宁总队医院五官科,沈阳110034 [2]武警辽宁总队医院检验科,沈阳110034 [3]武警辽宁总队医院卫勤处,沈阳110034 [4]武警辽宁总队医院内二科,沈阳110034 [5]解放军第九六七医院眼科,大连116021

出　　处：《中国医师进修杂志》2020年第6期535-539,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨使用自体富血小板血浆(PRP)眼药水治疗中度至重度干眼(DED)的疗效及安全性。方法收集2018年3月至2019年10月武警辽宁总队医院和解放军第九六七医院诊治的中度至重度DED患者395例(790眼)。采用随机数字表法分为采用自体PRP治疗的自体PRP治疗组(196例,392只眼)和采用人工泪液治疗的对照组(199例,398只眼)。观察两组治疗前后的DED主观症状、Schirmer试验(ST)、角膜荧光素染色(CFS)和眼表疾病指数(OSDI)的变化情况。结果治疗1个疗程后,两组ST值均升高,与治疗前比较差异有统计学意义(P<0.05)。治疗后,两组OSDI评分和CFS评分均降低,PRP治疗组治疗前后OSDI评分和CFS评分比较差异有统计学意义(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05)。治疗后,PRP治疗组OSDI评分和CFS评分低于对照组[(16.8±18.7)分比(43.2±14.5)分,(0.21±0.53)分比(1.62±0.69)分],差异有统计学意义(P<0.05)。治疗1个疗程后,自体PRP治疗组总有效率高于对照组[80.1%(157/196)比51.76%(103/196)],差异有统计学意义(P<0.05)。结论自体PRP对中重度DED患者进行治疗,能够最大程度地改善患者眼部不适等症状,疗效确切,且安全性较好。Objective To evaluate the efficacy and safety of using platelet-rich plasma(PRP)eyedrops for the treatment of moderate to severe dry eye disease(DED).Methods A total of 395 patients(790 eyes)with moderate to severe DED diagnosed and treated in the Armed Police Liaoning Corps Hospital and the PLA 967 Hospital from March 2018 to October 2019 were collected.Random number table method was used to divide into autologous PRP treatment group(196 cases,392 eyes)treated with autologous PRP and control group(199 cases,398 eyes)treated with artificial tears.The changes of subjective symptoms of DED,Schirmer test(ST),corneal fluorescein staining(CFS)and Ocular Surface Disease Index(OSDI)before and after treatment were observed in both groups.Results After 1 course of treatment,the ST values of both groups increased,which was statistically significant compared with before treatment(P<0.05).After treatment,the OSDI and CFS scores of the two groups were reduced.The difference in OSDI and CFS scores of the PRP treatment group before and after treatment was statistically significant(P<0.05),and there was no statistically significant difference in the control group before and after treatment(P>0.05).After treatment,the OSDI and CFS scores of the PRP treatment group were lower than those of the control group[(16.8±18.7)scores vs.(43.2±14.5)scores,(0.21±0.53)scores vs.(1.62±0.69)scores],the differences were statistically significant(P<0.05).After one course of treatment,the total effective rate of the autologous PRP treatment group was higher than that of the control group[80.1%(157/196)vs.51.76%(103/196)],the difference was statistically significant(P<0.05).Conclusions Autologous PRP can treat patients with moderate-to-severe autologous PRP treatment group,which can greatly improve patients'eye discomfort and other symptoms.

关 键 词：干眼 自体富血小板血浆 富含生长因子血浆 疗效比较研究 

分 类 号：R777.34[医药卫生—眼科]