食品中化学性有害物的质谱软电离裂解规律及筛查技术研究进展  

Research progress on the fragmentation mechanisms of mass spectrometry soft ionization and screening of chemical hazardous substances in food

作　　者：刘晓敏[1,2] 许秀丽[1] 聂雪梅[1] 国伟[1] 张峰[1] LIU Xiaomin;XU Xiuli;NIE Xuemei;GUO Wei;ZHANG Feng(Institute of Food Safety,Chinese Academy of Inspection and Quarantine,Beijing 100176,China;China Medical University,Shenyang 110122,China)

机构地区：[1]中国检验检疫科学研究院食品安全研究所,北京100176 [2]中国医科大学,辽宁沈阳110122

出　　处：《色谱》2020年第7期750-758,共9页Chinese Journal of Chromatography

基　　金：国家重点研发计划(2018YFC1602403);国家“万人计划”科技创新领军人才项目(张峰).

摘　　要：食品中化学性有害物是导致食品安全问题的重要原因,质谱是对食品中化学性有害物进行定性定量分析的有效方法。该文按照化合物结构类别,综述了食品中重要化学性有害物的质谱软电离裂解机理,包括农药、兽药、真菌毒素,以及其他化学污染物。对于每类化合物,重点综述化合物质谱裂解产生的特征碎片、中性丢失等,以及这些质谱软电离裂解机理在食品中化学性有害物筛查及发现中的应用。研究化合物的质谱裂解机理可以帮助研究者对化合物进行结构解析和结构确证,为食品中同类结构新型化学性有害物的发掘提供理论依据。Hazardous chemicals in food are an important cause of food safety problems.Mass spectrometry is an effective tool for the qualitative and quantitative analysis of these substances.In this paper,the fragmentation mechanisms for several chemical hazardous substances,including pesticides,veterinary drugs,mycotoxins,and other chemical pollutants classified by structural analogs,are reviewed.For each class of compounds,we summarize the characteristic fragments and neutral loss generated by cleavage in the mass spectrometry analysis.We also summarize the mechanisms applied to screen and discover new structural analogs in food.This review can help researchers analyze and confirm the structure of compounds and provide a theoretical basis for the discovery of new structural analogs in food.

关 键 词：裂解规律 软电离 质谱 特征碎片 非定向筛查 未知化合物 综述 

分 类 号：O658[理学—分析化学]