GDNF与消化系统肿瘤关系研究进展  

Research of relation between glial cell line-derived neurotrophic factor and digestive system tumor

作　　者：王小娟 李小丽[1] 金正旭 张德奎[1] WANG Xiao-juan;LI Xiao-li;JIN Zheng-xu;ZHANG De-kui(Department of Gastroenterology,the Second Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二医院消化内科,甘肃兰州730000

出　　处：《基础医学与临床》2020年第7期986-989,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81470808)。

摘　　要：肠神经胶质细胞源性神经生长因子(GDNF)及其受体(RET)的异常表达与消化系统肿瘤的发生、发展及预后相关。胰腺癌中,GDNF及其受体RET与周围神经侵袭相关并呈剂量依赖性,RET(-)癌细胞则失去了侵袭并且破坏神经的能力;结肠癌中,RET突变促进结肠癌细胞增殖、迁移及存活,且与结肠癌患者预后较差相关;肝癌中,GDNF可独立于血管源性生长因子促进肝癌组织血管生成,为肿瘤细胞的增殖侵袭提供充足的营养;胃癌中发现GFRα3启动子区域甲基化,且其程度和术后患者存活率之间呈反比关系。Abnormal expression of GDNF(glial cell line-derived neurotrophic factor)and its receptor(RET)are associated with the emergence and development of tumors in the digestive system.GDNF and RET are associated with peripheral nerve invasion with a dose-dependent manner in pancreatic cancer,while RET(-)cancer cells lose the ability to invade and destroy nerves.RET mutations promote the proliferation,migration and survival of colon cancer cells,and are associated with poor prognosis of colon cancer patients.GDNF can promote the angiogenesis of liver cancer tissues independently of vasogenic growth factor,providing sufficient nutrition for the growth and invasion of tumor cells.Methylation of the GFR 3 promoter was found in gastric cancer,and the degree of methylation was negatively related to postoperative survival of patients.

关 键 词：肠神经胶质细胞源性神经营养因子 肝癌 结直肠癌 胰腺癌 胃癌 

分 类 号：R735[医药卫生—肿瘤]