内皮间质转化在胶质瘤中的研究现状及其靶向治疗策略  

The endothelial-mesenchymal transition in glioma and strategies for targeted therapy:research progress

作　　者：曹海红 殷志新[2] 韩西群[2] 袁小澎[3] 王启瑞[1] CAO Hai-hong;YIN Zhi-xin;HAN Xi-qun;YUAN Xiao-peng;WANG Qi-rui(School of Traditional Chinese Medicine,Southern Medical University,Guangzhou,510315,China;School of Basic Medical Science,Southern Medical University,Guangzhou 510315,China;Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学中医药学院,广州510315 [2]南方医科大学基础医学院,广州510315 [3]南方医科大学珠江医院,广州510315

出　　处：《国际药学研究杂志》2020年第4期243-250,共8页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金面上项目(81873295);广东省自然科学基金资助项目(2018A030313106,2019A1515012209);广东省中医药局资助项目(20181169)。

摘　　要：内皮间质转化(EndoMT)是指在一定的刺激因素作用下,内皮细胞失去其特征性表型、功能及形态而逐渐向间质细胞转化的一种病理生理过程。越来越多的研究表明,EndoMT在胶质瘤的发生发展及侵袭转移等病理过程中发挥着关键作用,本文综述了EndoMT相关信号通路及其在胶质瘤异常血管生成、侵袭转移、免疫抑制、耐药等方面的重要作用,总结了以其为靶点的治疗策略,为研究其在胶质瘤发生发展及治疗中的作用提供理论基础和科学依据,为临床治疗该病提供参考。Endothelial-mesenchymal transition(EndoMT)is a pathophysiological progress that endothelial cells lose their specific phenotype,function and morphology and gradually transform to mesenchymal cells under the effect of certain stimulating factors.More and more researches have shown that EndoMT plays a key role in the occurrence and development as well as the invasion and metastasis of glioma.This paper reviews the EndoMT-related signaling pathways and their important effect on the angiogenesis,invasion,metastasis,immunosuppression and the drug resistance of glioma.Meanwhile,strategies for the EndoMT-targeted therapy are also summarized,so as to provide a reference for related studies and clinical treatment of glioma.

关 键 词：内皮间质转化 信号通路 治疗靶点 胶质瘤 

分 类 号：R739.41[医药卫生—肿瘤]