砷制剂抗淋巴瘤作用研究进展  

Anti-lymphoma effect of arsenic preparations:research advances

作　　者：李旭[1,2] 姜爽[2] 樊磊 张英杰[2] 史丹[2] 王晓波 LI Xu;JIANG Shuang;FAN Lei;ZHANG Ying-jie;SHI Dan;WANG Xiao-bo(Dalian Medical University,Dalian 116044,China;Department of Pharmacy,The 967th Hospital of Joint Logistics Force,Dalian 116021,China)

机构地区：[1]大连医科大学,大连116044 [2]中国人民解放军联勤保障部队第967医院药剂科,大连116021

出　　处：《国际药学研究杂志》2020年第4期258-262,共5页Journal of International Pharmaceutical Research

基　　金：中国医药教育协会科学技术研究面上资助项目(2016SKT-M010)。

摘　　要：砷最早被认为是有毒物质,譬如,三氧化二砷(砒霜)有剧毒,但近年来,砷化合物在肿瘤治疗方面发挥着重要的作用。许多研究表明,砷制剂抗肿瘤作用广泛,在治疗白血病方面疗效尤为显著,但对淋巴瘤的治疗研究较少。本文对砷制剂抗淋巴瘤研究进展及作用机制进行综述,以期为更多的砷制剂治疗淋巴瘤相关研究提供参考。Arsenic was originally regarded as a toxic substance.For example,arsenic trioxide is highly toxic.But in recent years,arsenic compounds have played an important role in cancer treatment.Many studies have shown that arsenic preparations have a wide range of anti-tumor effects,especially with the significant effect seen in the treatment of leukemia.However,there have been few studies on the therapeutic effect of arsenic preparations on lymphoma so far.This paper reviews the research progress in the antilymphoma effect and related action mechanism of arsenic preparations,so as to provide a reference for further studies on the lymphoma treatment with arsenic preparations.

关 键 词：砷制剂 淋巴瘤 抗淋巴瘤作用机制 

分 类 号：R730[医药卫生—肿瘤] R733.41[医药卫生—临床医学]