内镜黏膜下剥离术治疗早期食管癌的临床疗效  

Clinical efficacy of endoscopic submucosal dissection in treatment of early esophageal cancer

作　　者：李振涛 姚建宁[2] 丁辉[3] LI Zhentao;YAO Jianning;DING Hui(Department of Gastroenterology,Dengfeng People’s Hospital,Dengfeng 452470,He’nan,China;Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,He’nan,China;Department of Gastroenterology,He’nan Provincial People’s Hospital,Zhengzhou 450000,He’nan,China)

机构地区：[1]登封市人民医院消化内科,河南登封452470 [2]郑州大学第一附属医院消化科,郑州450000 [3]河南省人民医院消化科,郑州4500000

出　　处：《癌症进展》2020年第11期1130-1132,1177,共4页Oncology Progress

摘　　要：目的探讨内镜黏膜下剥离术治疗早期食管癌的临床疗效。方法依据随机数字表法将100例早期食管癌患者分为对照组和观察组,每组50例,对照组患者给予内镜黏膜下切除术,观察组患者给予内镜黏膜下剥离术。观察并比较两组患者的手术一般情况、并发症发生情况、1年复发率及治疗满意度。结果观察组患者的剥离面积大于对照组,一次性完整切除率高于对照组,差异均有统计学意义(P﹤0.05);两组患者的一次性整块切除率比较,差异无统计学意义(P﹥0.05)。观察组患者的并发症总发生率为2%(1/50),低于对照组的14%(7/50),差异有统计学意义(P﹤0.05)。对照组和观察组患者的1年复发率分别为6%(3/50)和2%(1/50),差异无统计学意义(P﹥0.05)。观察组患者的治疗满意率为98%,高于对照组的84%,差异有统计学意义(P﹤0.05)。结论内镜黏膜下剥离术治疗早期食管癌的疗效较好,患者满意度高,具有良好的应用价值。Objective To explore the clinical efficacy of endoscopic submucosal dissection in the treatment of early esophageal cancer.Method Totally,100 patients with early esophageal cancer who underwent surgical treatment were included in the research as control group and study group,with 50 cases in each,the control group was treated with endoscopic submucosal resection,and the study group was administered with endoscopic submucosal dissection.The general conditions during surgery,incidence of complications,and 1-year recurrence rate and satisfaction level of treatment were compared between the two groups.Result The dissection area in study group was larger than that in control group,with higher rate of one-time complete resection in study group versus control group(P<0.05);while similar en bloc resection rate was noted between the two groups(P>0.05).The overall incidence rate of complications in study group was 2%(1/50),which was lower than the 14%(7/50)observed in control group(P<0.05).The 1-year recurrence rate was 6%(3/50)and 2%(1/50)in control group and study group,respectively,with no significant difference noted(P>0.05).98%patients in study group were satisfied with the treatment,and was notably higher compared to 84%in control group(P<0.05).Conclusion Endoscopic submucosal dissection is effective in the treatment of early esophageal cancer,with high satisfaction level in patients,demonstrating the value for applying in practice.

关 键 词：内镜黏膜下剥离术 食管癌 并发症 复发率 

分 类 号：R735.1[医药卫生—肿瘤]