氟伏沙明联合阿立派唑对强迫症患者临床症状的改善作用  

Effect of Fluvoxamine and Aripiprazole on Clinical Symptoms of OCD Patients

作　　者：彭铃武 陈铭 PENG Lingwu;CHEN Ming(Second Department of Psychiatry,Fu'an Mental Hospital of Ningde,Ningde Fujia 355000,China)

机构地区：[1]宁德市福安精神病人疗养院精神二科,福建宁德355000

出　　处：《中国卫生标准管理》2020年第11期87-89,共3页China Health Standard Management

摘　　要：目的探讨对强迫症患者治疗期间应用氟伏沙明和阿立哌唑联合治疗的效果及安全性。方法本次筛选病例时间范围为2019年2月-11月,筛选出66例来本院治疗的强迫症患者,根据来院治疗时间分为试验组33例和参照组33例,分别予以氟伏沙明+阿立哌唑、氟伏沙明治疗。观察并比较两组患者的生活质量、焦虑情绪、强迫症症状、不良反应。结果治疗前,两组各项临床指标评分并无较大差异,P>0.05。治疗后,试验组患者的生活质量(328.79±72.57)分明显高于参照组(272.17±68.84)分,试验组焦虑情绪明显少于参照组,试验组强迫症症状改善情况明显好于参照组,且试验组出现不良反应的患者(2例)明显少于参照组(9例),数据对比有统计学意义,P<0.05。结论氟伏沙明和阿立哌唑在应用过程中,可有效改善强迫症患者临床症状,增强患者认知功能,减少不良反应,提高患者生活质量。Objective To explore the effect and safety of combined treatment of fluvoxamine and aripiprazole in patients with obsessivecompulsive disorder.Methods The time range of this screening case was from February to November 2019.66 patients with obsessive-compulsive disorder who were treated in our hospital were selected.According to the time of hospital treatment,they were divided into 33 cases in the experimental group and 33 cases in the reference group.Fluvoxamine+aripiprazole,fluvoxamine were treated respectively.Observe and compare the quality of life,anxiety,symptoms of obsessive-compulsive disorder,and adverse reactions in the two groups of patients.Results Before treatment,there was no significant difference in the scores of clinical indicators between the two groups,P>0.05.After treatment,the quality of life of patients in the test group(328.79±72.57)was significantly higher than the reference group(272.17±68.84).The anxiety of the test group was significantly less than that of the reference group.The improvement of the symptoms of obsessive-compulsive disorder in the test group was significantly better than that of the reference group.The number of patients with adverse reactions in the test group(2 cases)was significantly less than that in the reference group(9 cases).The data comparison was statistically significant,P<0.05.Conclusion In the application process of fluvoxamine and aripiprazole,they can effectively improve the clinical symptoms of patients with obsessive-compulsive disorder,enhance their cognitive function,reduce adverse reactions,and improve their quality of life.

关 键 词：氟伏沙明 阿立哌唑 强迫症患者 临床症状 认知功能 不良反应 

分 类 号：R749[医药卫生—神经病学与精神病学]