盐碘含量调整前后十堰市新生儿TSH结果的变化  

Changes of suspicious neonatal hypothyroidism in Shiyan with iodine content adjustment

作　　者：雷赛 罗慧丽 王静[2,4] 李菊 杨丽婷 李冬[1] 邓婓 余可斐 郭怀兰 LEI Sai;LUO Hui-li;WANG Jing;LI Ju;YANG Li-ting;LI Dong;DENG Fei;YU Ke-fei;GUO Huai-lan(School of Nursing,Hubei University of Medicine,Shiyan 442000,China;不详)

机构地区：[1]湖北医药学院护理学院,湖北十堰442000 [2]湖北医药学院南水北调水源区环境与健康研究中心,湖北十堰442000 [3]十堰市妇幼保健院,湖北十堰442000 [4]湖北医药学院公共卫生与管理学院,湖北十堰442000 [5]十堰市太和医院,湖北十堰442000

出　　处：《现代预防医学》2020年第12期2159-2161,2165,共4页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(81372998);湖北医药学院2016创新团队项目(FDFR201602)。

摘　　要：目的回顾十堰市城区及各县市区新生儿促甲状腺激素(TSH)筛查情况,以了解盐碘含量调整对胎儿和新生儿碘营养状况的影响,为科学调整本地区盐碘含量提供依据。方法采集2010年和2016年十堰市各县市区新生儿足跟血,进行新生儿疾病筛查。采用免疫荧光法测定足跟血血清促甲状腺激素,并对结果进行卡方检验分析。结果在同一年间,十堰市城区和各县市新生儿足跟血TSH阳性率差异有统计学意义(2010年:χ^2=14.03,P<0.05;2016年:χ^2=0.09,P<0.05),但TSH阳性率性别和城乡差异均无统计学意义(2010年性别:χ^2=0.11,P>0.05;2010年城乡:χ^2=2.12,P>0.05;2016年性别:χ^2=0.77,P>0.05;2016年城乡:χ^2=0.73,P>0.05)。与2010年相比,十堰市2016年TSH阳性率显著上升(χ^2=170.77,P<0.05)。结论十堰市新生儿可疑CH病例的发生呈现地区性分布的特点,不同地区的发病率具有较大差异。在2012年盐碘含量下调后,十堰市新生儿TSH阳性率显著上升。Objective To investigate the thyroid stimulating hormone(TSH)level of newborns for further scientific adjustment of salt iodine content in Shiyan.Methods Neonatal heel blood were collected in 2010 and 2016,and the serum thyrotropin was determined by immunofluorescence assay.Results In the same year,the TSH positive rate was statistically different in different areas of Shiyan(In 2010:χ^2=14.03,P<0.05;In 2016:χ^2=0.09,P<0.05),but there was no statistic difference in TSH positive rate between genders and between urban and rural(gender difference in 2010:χ^2=0.11,P>0.05;rural-urban differences in 2010:χ^2=2.12,P>0.05;gender difference in 2016:χ^2=0.77,P>0.05;rural-urban differences in 2016:χ^2=0.73,P>0.05).Moreover,the TSH positive rate increased in 2016 compared to 2010(χ^2=170.77,P<0.05).Conclusion The morbidity of suspected CH of newborns possesses regional distribution character in Shiyan.With the reduction of salt iodine content in 2012,the TSH positive rate of newborns significantly increases.

关 键 词：新生儿 碘含量 促甲状腺激素 先天性甲状腺功能减低症 

分 类 号：R151.4[医药卫生—营养与食品卫生学]