急性缺血性卒中患者血清胱抑素C水平与脑白质疏松严重程度的相关性研究  

Association between serum cystatin C level and leukoaraiosis in patients with acute ischemic stroke

作　　者：王建[1] 曹树刚[1] 张文婷 王嵘峰[1] 夏明武[1] 徐文安[1] WANG Jian;CAO Shu-gang;ZHANG Wen-ting(Department of Neurology,the Second People's Hospital of Hefei,Hefei 230011,China)

机构地区：[1]合肥市第二人民医院神经内科,230011

出　　处：《临床神经病学杂志》2020年第3期171-174,共4页Journal of Clinical Neurology

摘　　要：目的探讨急性缺血性卒中患者血清胱抑素C水平与脑白质疏松严重程度的相关性。方法选择192例行头颅MRI检查的急性缺血性卒中患者,应用Fazekas评分量表将合并脑白质疏松的急性缺血性卒中患者分为轻度组27例,中度组96例,重度组69例。收集3组患者包括血清胱抑素C水平在内的各项临床资料。结果年龄、三酰甘油、肌酐等在3组间比较差异有统计学意义(均P<0.05),轻度组、中度组、重度组血清胱抑素C水平依次升高,差异均有统计学意义(均P<0.05)。有序多分类Logistic回归分析显示血清胱抑素C水平是脑白质疏松严重程度增加的独立危险因素(OR=4.669,P=0.042);Spearman相关分析显示,血清胱抑素C水平与脑白质疏松严重程度呈正相关(r=0.371,P=0.000)。结论血清胱抑素C水平升高与急性缺血性卒中患者脑白质疏松的严重程度独立相关。Objective To investigate the relationship between serum cystatin C(CysC)level and leukoaraiosis(LA)in the patients with acute ischemic stroke.Methods A total of one hundred ninety two acute ischemic stroke patients were detected by brain MRI.According to Fazekas score,the severity of LA patients with acute ischemic stroke were divided into mild group(n=27),moderate group(n=96)and severe group(n=69).The clinical data including serum CysC of patients were collected.Results There were significant differences in the age,triglyceride and creatinine among three groups(all P<0.05).The levels of serum CysC were increased with the increasing of disease severity(all P<0.05).Logistic regression analysis showed that serum CysC was an independent risk factor for the severity of LA(OR=4.669,P=0.042).Spearman rank correlation analysis showed that serun CysC were positively correlated with the severity of LA(r=0.371,P=0.000).Conclusion In patients with acute ischemic stroke,the serum CysC level is independently associated with the severity of LA.

关 键 词：胱抑素C 卒中 脑缺血 脑白质疏松症 MRI 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]