FGF21与溃疡性结肠炎小鼠相关性研究  

Correlation between FGF21 and ulcerative colitis in mice

作　　者：夏秀秀 倪铭 陆祎婷 赵翠青[2] 王沛茹 金宁一[2] 刘立明 Xia Xiuxiu;Ni Ming;Lu Yiting;Zhao Cuiqing;Wang Peiru;Jin Ningyi;Liu Liming(College of Life and Environmental Science,Wenzhou University,Zhejiang Wenzhou 325035;Institute of Virology Wenzhou University,Wenzhou University,Zhejiang Wenzhou 325035;School of Phamaceutical,Wenzhou medical university,Wenzhou,Zhejiang Wenzhou 325035;Animal Science and Technology College,Jilin Agricultural Science Technology University,Jilin Jilin 132101)

机构地区：[1]温州大学生命与环境科学学院,浙江温州325035 [2]温州大学病毒学研究所,浙江温州325035 [3]温州医科大学药学院,浙江温州325035 [4]吉林农业科技学院动物科技学院,吉林吉林132101

出　　处：《现代畜牧兽医》2020年第4期8-13,共6页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：突发急性传染病诊断试剂参考品及评价技术研究(项目编号:2018ZX10102-001-001-003);浙江省自然科学基金项目(项目编号:LGF19H070002,LGF19H030012);吉林农业科技学院博士启动基金项目(项目编号:20190145,20190330);吉林农业科技学院大学生科技创新基金资助项目(项目编号:2019076)。

摘　　要：探究在溃疡性结肠炎小鼠与成纤维细胞生长因子21(FGF21)的之间的相关性。本研究使用葡聚糖硫酸钠(DSS)诱导小鼠溃疡性结肠炎,分析小鼠外周血中FGF21的含量与小鼠体重变化、疾病活动指数(DAI)评分、直肠长度和结肠炎评分之间的相关性。结果显示,在溃疡性结肠炎小鼠中,外周血中的FGF21的含量与小鼠体重变化和直肠长度呈负相关,与疾病活动指数(DAI)评分和结肠炎评分呈正相关。溃疡性结肠炎小鼠外周血中的FGF21含量与疾病活动程度相关,FGF21或许可以作为检测溃疡性结肠的生物学指标。To explore the correlation between ulcerative colitis mice and fibroblast growth factor 21(FGF21).Methods:In this study,dextran sodium sulfate(DSS)was used to induce ulcerative colitis in mice.The amount of FGF21 in mouse peripheral blood and changes in mouse body weight,disease activity index(DAI)score,rectal length,and colitis were analyzed.Correlation between ratings.The results showed that,in ulcerative colitis mice,the content of FGF21 in peripheral blood was negatively correlated with changes in mouse body weight and rectal length,and positively correlated with disease activity index(DAI)score and colitis score.The level of FGF21 in peripheral blood of mice with ulcerative colitis is related to the degree of disease activity.FGF21 may be used as a biological test for ulcerative colon。

关 键 词：成纤维细胞生长因子21 溃疡性结肠炎 相关性分析 

分 类 号：R574.62[医药卫生—消化系统]