结肠癌组织KAI1表达与肿瘤复发的相关性研究  

Correlation between KAI1 expression in colon cancer tissues and tumor recurrence

作　　者：王哲彦[1] 马志红[2] 刘文博[3] 鲁翠芳 李红民[1] 徐丽晓[4] Wang Zheyan;Ma Zhihong;Liu Wenbo;Lu Cuifang;Li Hongmin;Xu Lixiao(Department of Pathology,Tangshan People's Hospital in Hebei Province,Tangshan 063001,China;Department of Clinical Laboratory,the Second Hospital of Tangshan in Hebei Province,Tangshan 063015,China;Department of Internal Medicine,the Ninth Hospital of Tangshan in Hebei Province,Tangshan 063099,China;Department of Clinical Laboratory,People's Hospital of Zunhua in Hebei Province,Zunhua 064200,China)

机构地区：[1]河北省唐山市人民医院病理科,063001 [2]河北省唐山市第二医院检验科,063015 [3]河北省唐山市第九医院内科,063099 [4]河北省遵化市人民医院检验科,064200

出　　处：《肿瘤研究与临床》2020年第5期347-351,共5页Cancer Research and Clinic

基　　金：河北省医学科学研究重点课题(20181235)。

摘　　要：目的探讨结肠癌组织中KAI1表达对患者肿瘤复发的预测价值。方法选取2010年8月至2011年11月唐山市人民医院92例接受结肠癌根治术患者的病理组织标本,根据随访结果将患者分为肿瘤复发组(33例)和未复发组(59例)。采用免疫组织化学法检测患者癌组织中KAI1表达。采用χ2检验分析KAI1表达与结肠癌患者临床病理特征的关系,Spearman法分析KAI1表达与患者复发时间的关系,Cox比例风险模型分析影响结肠癌术后复发的相关因素。结果肿瘤复发组癌组织中KAI1阳性率低于未复发组[39.39%(13/33)比62.71%(37/59)],差异具有统计学意义(χ2=4.638,P=0.031)。KAI1表达与结肠癌患者的性别、年龄及肿瘤最大径均无关(均P>0.05),而与肿瘤的分化程度及淋巴结转移有关[高、中分化比低分化:70.3%(26/37)比43.6%(24/55),χ2=6.324,P=0.012;淋巴结转移比未转移:43.2%(19/44)比64.6%(31/48),χ2=4.238,P=0.039]。癌组织中KAI1表达与肿瘤复发时间呈正相关(r=0.845,P<0.05)。Cox多因素分析表明,肿瘤低分化、淋巴结转移及KAI1阴性表达为结肠癌术后复发的独立危险因素(HR=1.736,95%CI 1.598~5.391,P=0.019;HR=1.526,95%CI 1.175~3.029,P=0.037;HR=1.799,95%CI 1.756~5.825,P=0.013)。结论结肠癌组织中KAI1低表达与肿瘤复发密切相关,检测结肠癌组织中KAI1表达对预测患者肿瘤复发具有一定的价值。Objective To investigate the predictive value of KAI1 expression in colon cancer tissues for tumor recurrence.Methods Ninety-two pathological tissue samples were collected from patients undergoing radical operation for colon cancer in Tangshan People's Hospital from August 2010 to November 2011.According to the results of follow-up,the patients were divided into recurrent group(33 cases)and non-recurrent group(59 cases).KAI1 expression in tumor tissues was detected by immunohistochemistry.χ2 test was used to analyze the relationship between KAI1 expression in colon cancer tissues and clinicopathological characteristics of patients with colon cancer.Spearman correlation test was used to analyze the relationship between KAI1 expression in colon cancer tissues and the recurrence time of patients.Cox proportional hazards model was used to analyze the related factors affecting postoperative recurrence of colon cancer.Results KAI1 expression in tumor tissues in the recurrent group was lower than that in the non-recurrent group[39.39%(13/33)vs.62.71%(37/59),χ2=4.638,P=0.031].KAI1 expression was not associated with patients'gender,age and tumor maximum diameter(all P>0.05),but related to the tumor differentiation and lymphatic metastasis[high and medium differentiation vs.low differentiation:70.3%(26/37)vs.43.6%(24/55),χ2=6.324,P=0.012;lymph node metastasis vs.non-lymph node metastasis:43.2%(19/44)vs.64.6%(31/48),χ2=4.238,P=0.039].KAI1 expression in tumor tissues was positively correlated with tumor recurrence time(r=0.845,P<0.05).Cox multivariate analysis showed that the low differentiation of the tumor,lymph node metastasis and negative expression of KAI1 in colon cancer tissues were independent risk factors for recurrence of colon cancer after surgery(HR=1.736,95%CI 1.598-5.391,P=0.019;HR=1.526,95%CI 1.175-3.029,P=0.037;HR=1.799,95%CI 1.756-5.825,P=0.013).Conclusion Low KAI1 expression in colon cancer tissues is closely related to colon cancer recurrence,and the detection of KAI1 expression in colon cancer tissues

关 键 词：结肠肿瘤 基因 肿瘤抑制 KAI1 复发 

分 类 号：R735[医药卫生—肿瘤]