超声联合CT检查在肝恶性肿瘤射频消融治疗中的应用价值探讨  

Short-term efficacy ofradiofrequency ablation in patients with hepatic malignant tumors under ultrasound-or US and CT combination-guidance

作　　者：郑雪[1] 宣之东[1] 王玉[1] 张丽静[2] Zheng Xue;Xuan Zhidong;Wang Yu(Third Department of Ultrasound,Central Hospital,Cangzhou 061000,Hebei Province)

机构地区：[1]河北省沧州市中心医院超声三科,061000 [2]河北医科大学沧州临床学院

出　　处：《实用肝脏病杂志》2020年第4期589-592,共4页Journal of Practical Hepatology

基　　金：河北省沧州市科学技术局科研项目(编号:172302038)。

摘　　要：目的探讨超声联合计算机断层扫描(CT)引导下射频消融(RFA)治疗肝恶性肿瘤患者的疗效。方法2017年3月~2019年1月我院收治的肝恶性肿瘤患者96例,均接受射频消融治疗,其中46例在超声引导下,50例在超声联合CT引导下行RFA治疗。在术后3个月复查MRI,评估疗效。结果在RFA治疗3个月后,超声联合CT引导组总有效率为94. 0%,显著高于超声引导组的80. 4%(P<0. 05);在RFA治疗后两组并发症发生率分别为4. 0%和13. 0%,差异无统计学意义(P>0. 05);治疗后,超声联合CT引导组血清肌酐和AFP水平分别为(71. 5±7. 2)μmol/L和(30. 4±5. 7)μg/L,与超声引导组的(70. 6±7. 3)μmol/L和(31. 8±5. 6)μg/L比,差异无统计学意义(P>0. 05)。结论在行RFA治疗肝恶性肿瘤患者时,采取超声联合CT检查引导可保证穿刺更精确,消融效果更好,且并发症发生率低,具有很大的临床应用价值。Objective The aim of this study was investigate the short-term efficacy of radiofrequency ablation(RFA)in patients with hepatic malignant tumors under ultrasound(US)-or US and CT combination-guidance.Methods A retrospective study was conducted on 96 patients with hepatic malignant tumors who underwent RFA under US and CT-guidance(group A)or US-guidance(group B)in our hospital from March 2017 through January 2019.All patients received RFA therapy,and were followed-up for three months.Results At the end of three months after RFA treatment,the total response rate in group A was significantly higher than that in group B(94.0%vs.80.4%,P<0.05);after RFA treatment,there was no significant difference in incidence of complications between the two groups(4.0%vs.13.0%,P>0.05);there were no significant differences as respect to serum creatinine and AFP levels between the two groups[(71.5±7.2)μmol/L vs.(70.6±7.3)μmol/L and(30.4±5.7)μg/L vs.(31.8±5.6)μg/L,respectively,P>0.05].Conclusion The short-term efficacy of RFA guided by ultrasound and CT combination in the treatment of patients with hepatic malignant tumors is better as compared with routine ultrasound guidance,with low postoperative incidence of complications,which might be due to precise guidance and total ablation.

关 键 词：肝恶性肿瘤 射频消融 超声引导 计算机断层扫描引导 治疗 

分 类 号：R735.7[医药卫生—肿瘤]