中药抑制卵巢癌机制研究进展  

Advances on of Trtaditional Chinese Herbs Inhibiting Ovarian Cancer Mechanism

作　　者：白生菊 魏锁成[1] BAI Sheng-ju;WEI Suo-cheng(Life Science and Engineering College,Northwest Minzu University,Lanzhou 730030,China)

机构地区：[1]西北民族大学生命科学与工程学院,甘肃兰州730030

出　　处：《西北民族大学学报（自然科学版）》2020年第2期59-63,66,共6页Journal of Northwest Minzu University(Natural Science)

基　　金：西北民族大学研究生科研创新项目(Yxm2020127)。

摘　　要：中药在抗肿瘤中起着重要的作用,不仅能抑制恶性肿瘤的生长,还能提高化疗药物治疗的敏感性.通过对具有抑制卵巢癌效果的大黄、红花、雷公藤等10种中药的作用机制及其对化疗药物疗效的影响进行分析研究,结果显示大黄、红花、雷公藤等中药对卵巢癌细胞的抑制作用是通过JAK、MAPK、PI3K/AKT信号通路和细胞凋亡相关蛋白等机制实现的.这将为开发中药治疗卵巢癌的研究与临床应用提供科学参考.Traditional chinese herbs play an important role in anti-tumor.They not only can inhibit the growth of malignant tumors,but also improve the sensitivity of chemotherapy drugs.The present article reviewed the therapy mechanism of more than 10 traditional chinese herbs such as rhubarb,safflower and tripterygium wilfordii that have the effect of inhibiting ovarian cancer,and their effects on the efficacy of chemotherapy drugs.The inhibitory effect is achieved through JAK,MAPK,PI3K/AKT signaling pathway and apoptosis-related proteins.This will provide a scientific reference for the research and clinical application of the development of traditional Chinese herbs to treat ovarian cancer.

关 键 词：卵巢癌 中药 抑癌机制 化疗 

分 类 号：R737.31[医药卫生—肿瘤]