Glypican-1在脑胶质瘤中的表达及与临床病理特征和预后的关系  

Glypican-1 expression in gliomas and its relationship with clinicopathological features and prognosis

作　　者：贾国萍 李鑫 宋雨茜 宋涛[2] 王珊 Guo-ping Jia;Xin Li;Yu-xi Song;Tao Song;Shan Wang(Department of Pharmaceutical Engineering,School of Chemistry and Chemical Engineering,Central South University,Changsha,Hunan 410038,China;Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China)

机构地区：[1]中南大学化学化工学院制药工程系,湖南长沙410038 [2]中南大学湘雅医院神经外科,湖南长沙410008

出　　处：《中国现代医学杂志》2020年第14期19-23,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金面上项目(No:81872919)。

摘　　要：目的探究Glypican-1在脑胶质瘤中的表达、分布,以及与临床病理特征和预后的关系。方法通过免疫组织化学法检测Glypican-1在171例脑胶质瘤组织芯片中的表达及分布,分析其与脑胶质瘤患者临床病理特征及总生存期的关系。结果Glypican-1在脑胶质瘤细胞质、细胞膜中均有表达。不同年龄患者脑胶质瘤细胞质Glypican-1高表达率比较,差异有统计学意义(P<0.05);不同性别、肿瘤分级患者脑胶质瘤细胞质Glypican-1高表达率比较,差异无统计学意义(P>0.05)。肿瘤分级Ⅲ、Ⅳ级患者脑胶质瘤细胞膜Glypican-1表达水平高于Ⅰ、Ⅱ级患者(P<0.05);而不同性别、年龄患者脑胶质瘤细胞膜Glypican-1高表达率比较,差异无统计学意义(P>0.05)。不同脑胶质瘤细胞质Glypican-1表达水平患者的总生存期比较,差异无统计学意义(P>0.05);而脑胶质瘤细胞膜Glypican-1表达水平越高,患者总生存期越短(P<0.05)。年龄>50岁[HR=0.325(95%CI:0.185,0.570)]、肿瘤分级Ⅲ和Ⅳ级[HR=14.658(95%CI:6.835,31.432)]、Glypican-1在脑胶质瘤细胞膜中高表达[HR=2.351(95%CI:1.081,5.114)]是患者预后的影响因素。结论脑胶质瘤细胞膜Glypican-1表达水平与患者肿瘤分级有关,且脑胶质瘤细胞膜Glypican-1表达水平越高,总生存期越短。Objective To investigate the expression and distribution of Glypican-1 in glioma and the correlations with clinicopathology and prognosis.Methods The expression and distribution of Glypican-1 were detected by immunohistochemistry method in the tissue microarray from 171 glioma patients,and the correlations with clinicopathological features and overall survival of glioma patients were analyzed.Results Glypican-1 was expressed in both cytoplasm and cytomembrane of tumor cells in glioma tissues.Difference of the high expression rate of Glypican-1 in cytoplasm of glioma cells with different ages showed statistically significance(P<0.05).Difference of the high expression rate of Glypican-1 in cytoplasm of glioma cells with different genders and pathological grades showed no statistically significance(P>0.05).Glypican-1 expression in cytomembrane of glioma cells in Ⅲ and Ⅳ grade glioma was higher than that in Ⅰ and Ⅱ grade glioma(P<0.05).However,there was no significant difference in the rate of high expression of glypican-1 between different genders and ages(P>0.05).Difference of overall survival of glioma patients with different Glypican-1 expression in cytoplasm of tumor cells showed no statistically significance(P>0.05),while glioma patients with higher Glypican-1 expression in cytomembrane of glioma cells had shorter overall survival(P<0.05).Age>50 years old[HR=0.325(95%CI:0.185,0.570)],tumor grade Ⅲ and Ⅳ[HR=14.658(95%CI:6.835,31.432)]and high expression of glypican-1 in glioma cell membrane[HR=2.351(95%CI:1.081,5.114)]were the influencing factors of patients'prognosis.Conclusions Glypican-1 accumulation in cytomembrane of glioma cells in glioma is associated with high WHO grade(P<0.05)and low overall survival(P<0.05).

关 键 词：脑胶质瘤/神经胶质瘤 Glypican-1/Glypicans 细胞膜 病理学 临床 预后 

分 类 号：R739.41[医药卫生—肿瘤]