三种非甾体抗炎药物在超声乳化白内障吸除联合人工晶状体植入术围手术期的应用研究  

Clinical study of three non-steroidal anti-inflammatory drugs in the perioperative period of phacoemulsification surgery

作　　者：李妍 陈佩卿[1] 陈子和 徐佳[1] 陶永钢 Li Yan;Chen Peiqing;Chen Zihe;Xu Jia;Tao Yanggang(Eye Center of the second Affiliated Hospitai Medical College of Zhejiang University,Hangzhou 310000,China)

机构地区：[1]浙江大学医学院附属第二医院眼科中心,杭州310000

出　　处：《中华眼科医学杂志（电子版）》2020年第2期103-109,共7页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：国家自然科学基金项目(81700815)。

摘　　要：目的探讨三种非甾体抗炎药物在超声乳化白内障吸除联合人工晶状体植入术围手术期的疗效。方法选取2018年7月至2019年1月于浙江大学医学院附属第二医院眼科就诊并行白内障手术的患者122例(122只眼)进行研究。其中,男性36例(36只眼),女性86例(86只眼);年龄50~85岁,平均年龄(68.2±10.2)岁。采用数字表法将患者随机分为A组、B组及C组。全部行超声乳化白内障吸除联合人工晶状体植入术,并在围手术期分别滴用0.1%普拉洛芬滴眼液、0.1%溴芬酸钠滴眼液及0.1%双氯芬酸钠滴眼液。患者年龄、超声乳化能量及有效超声乳化时间采用(x±s)描述,组间比较采用单因素方差分析。患者眼压、前房闪辉、角膜中央厚度、术后干眼情况及自觉症状评分采用(x±s)描述,组间比较采用两因素重复测量方差分析。术后自觉症状重度患者的发生率采用眼数和百分比表示,并进行χ^2检验。结果 A组、B组及C组患者的眼压,术前分别为(13.55±2.88)mmHg(1 mmHg=0.133 kPa)、(13.16±3.71)mmHg及(13.83±2.74)mmHg;术后1 d分别为(15.21±3.71)mmHg、(14.46±4.78)mmHg及(14.73±4.04)mmHg;术后7 d分别为(14.19±3.34)mmHg、(13.66±3.46)mmHg及(14.56±3.65)mmHg;术后30 d分别为(12.68±2.69)mmHg、(12.16±3.65)mmHg及(12.89±3.17)mmHg,三组患者术前、术后1 d、术后7 d及术后30 d的差异均无统计学意义(F=0.49,0.12,0.65,0.59;P>0.05)。A组、B组及C组患者的前房闪辉值,术前分别为(6.09±2.98)pc/ms、(6.81±2.93)pc/ms及(7.31±5.87)pc/ms;术后1 d分别为(13.04±6.92)pc/ms、(12.72±11.53)pc/ms及(14.22±11.31)pc/ms;术后7 d分别为(7.77±3.73)pc/ms、(6.99±4.19)pc/ms及(8.14±3.15)pc/ms;术后30 d分别为(7.06±3.72)pc/ms、(8.21±3.16)pc/ms及(9.29±4.97)pc/ms,三组患者术前、术后1 d、术后7 d及术后30 d的差异均无统计学意义(F=0.90,0.25,0.97,2.99;P>0.05)。A组、B组及C组患者的角膜中央厚度,术前分别为(536.05±30.07)μm、(537.08±30.08)μm及(52Objective The aim of this study was to explore the effect of three non steroidal anti-inflammatory drugs in the perioperative period of phacoemulsification combined with intraocular lens implantation.Methods From July 2018 to January 2019,122 patients(122 eyes)with cataract surgery in Eye Center of the Second Affiliated Hospital,Zhejiang University Medical College were selected.Among them,36 cases(36 eyes)were male,86 cases(86 eyes)were female,and the average age was(68.2±10.2)years-old.The patients were randomly divided into A group,B group and C group.All patients were underwent phacoemulsification combined with intraocular lens implantation,and 0.1%pramiphene eye drops,0.1%sodium bromfenate eye drops and 0.1%diclofenac sodium eye drops were used in the perioperative period.The age,phacoemulsification energy and effective phacoemulsification time of patients were described by(x±s) and one-way ANOVA was used for comparison between groups.The scores of intraocular pressure,anterior chamber flash,central corneal thickness,postoperative dry eye condition and conscious symptoms were described by (x±s) and ANOVA.The incidence of severe postoperative symptoms was expressed by the number and percentage,and the chi-square test was performed.Results Intraocular pressure of all groups before operation were(13.55±2.88)mmHg(1 mmHg=0.133 kPa),(13.16±3.71)mmHg and(13.83±2.74)mmHg;1 d after operation,they were(15.21±3.71)mmHg,(14.46±4.78)mmHg and(14.73±4.04)mmHg,respectively;7 d after operation,they were(14.19±3.34)mmHg,(13.66±3.46)mmHg and(14.56±3.65)mmHg,respectively;30 d after operation,they were(12.68±2.69)mmHg,(12.16±3.65)mmHg and(12.89±3.17)mmHg,respectively.There was no significant difference among three groups before operation,1 d after operation,7 d after operation and 30 d after operation(F=0.49,0.12,0.65,0.59;P>0.05).All patients′anterior chamber flash value before operation were(6.09±2.98)pc/ms,(6.81±2.93)pc/ms and(7.31±5.87)pc/ms,respectively;1 d after operation,they were(13.04±6.92)pc/ms,(12.

关 键 词：非甾体类抗炎药 白内障超声乳化手术 眼压 房水闪辉 干眼 

分 类 号：R779.66[医药卫生—眼科]