[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪类衍生物的合成及生物活性研究进展  

Progress in Syntheses and Biological Activities of[1,2,4]Triazolo[3,4-b][1,3,4]thiadiazine Derivatives

作　　者：唐思雨 漆亚云 胡伟男 陈洁 朱梅 邵利辉 王贞超[1,2] 欧阳贵平 Tang Siyu;Qi Yayun;Hu Weinan;Chen Jie;Zhu Mei;Shao Lihui;Wang Zhenchao;Ouyang Guiping(School of Pharmacy,Guizhou University,Guiyang,550025;State Key Laboratory of Functions and Application of Medicinal Plants,Guizhou Medicinal University,Guiyang,550014;Guizhou Engineering Laboratory for Synthetic Drugs,Guiyang,550025)

机构地区：[1]贵州大学药学院,贵阳550000 [2]贵州医科大学药用植物功效与利用实验室,贵阳550014 [3]贵州省合成药物工程实验室,贵阳550025

出　　处：《化学通报》2020年第6期529-535,共7页Chemistry

基　　金：国家自然科学基金项目(21867004);药用植物功效与利用国家重点实验室项目(FAMP201801K);贵州省科技计划平台项目(黔科合平台人才20185781);贵州省科技计划项目(黔科合基础20181051)资助。

摘　　要：[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪作为极具前景的活性基团,在抗菌、抗肿瘤等方面具有多种药理活性,在药物和化学领域受到了广泛的关注。本文以含三唑并噻二嗪结构化合物的合成及其在抗肿瘤、抗菌等方面的生物活性为依据,对近几年国内外关于[1,2,4]三唑并[3,4-b][1,3,4]噻二嗪类化合物的研究进行分析总结,以期为后续该类新型抗肿瘤化合物的设计合成提供参考。The[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine as a promising active group has received extensive attention because of its pharmacological activities in antibacterial,anti-tumor and other aspects in the field of medicine and chemistry.In this paper,based on the syntheses of compounds containing triazolidazide structure and their anti-tumor,antibacterial and other activities in recent years,the research on[1,2,4]triazolazine[3,4-b][1,3,4]thiadiazine compounds was analyzed and summarized,so as to provide reference for the design and synthesis of these novel antitumor compounds.

关 键 词：[1 2 4]三唑并[3 4-b][1 3 4]噻二嗪 抗肿瘤 抑菌活性 

分 类 号：TQ463.5[化学工程—制药化工]