GSK-3β表达水平与胶质瘤患者预后的关系  

Relationship between GSK-3β and prognosis in patients with glioma

作　　者：赵凯[1] 王志武[1] 杨俊泉[1] ZHAO Kai;WANG Zhiwu;YANG Junquan(The First Department of Chemoradiotherapy,Tangshan People's Hospital,Hebei Province,Tangshan 063000,China)

机构地区：[1]唐山市人民医院放化疗一科,河北唐山063000

出　　处：《中国医药导报》2020年第17期113-116,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81603475)。

摘　　要：目的分析糖原合成酶激酶-3β(GSK-3β)表达水平与胶质瘤患者预后的关系。方法收集2010年1月~2014年12月河北省唐山市人民医院接收手术治疗胶质瘤148患者的组织标本和临床病理资料。根据GSK-3β表达水平将其分为GSK-3β高表达组(85例)和GSK-3β低表达组(63例)。收集两组年龄、性别、肿瘤长径(<4 cm,≥4 cm),肿瘤位置(额叶、颞叶、其他),WHO分级资料,免疫组化检测GSK-3β在组织中的表达,Kaplan-Meier分析和Cox回归分析GSK-3β表达与胶质瘤患者的预后关系。结果 GSK-3β表达水平与WHO分级明显相关(P <0.05)。GSK-3β高表达组的总生存时间短于GSK-3β低表达组(HR=2.31,95%CI:1.87~4.15,P <0.01)。GSK-3β高表达、WHO高分级是预后不良的影响因素。结论 GSK-3β高表达与胶质瘤患者的不良预后有关,是其不良预后的独立预测因子。Objective To analyze the relationship between glycogen synthase kinase-3β(GSK-3β)expression and prognosis of glioma patients.Methods Tissue specimens and clinical pathological data of 148 cases who received surgical treatment for glioma in Tangshan People′s Hospital of Hebei Province from January 2010 to December 2014 were collected.According to the expression of GSK-3β,they were devided into GSK-3βhigh-expression group(85 cases)and GSK-3βlow-expression group(63 cases).Age,gender,tumor length and diameter(<4 cm,≥4 cm),tumor location(frontal lobe,temporal lobe,others),WHO grading data of two groups were collected.Immunohistochemical analysis of GSK-3βexpression in tissues,Kaplan-Meier analysis and Cox regression analysis of the relationship between GSK-3βexpression and the prognosis of glioma patients.Results GSK-3βexpression level was significantly correlated with WHO grade(P<0.05).The total survival time of GSK-3βhigh-expression group was shorter than that of GSK-3βlow-expression group(HR=2.31,95%CI:1.87-4.15,P<0.01).High GSK-3βexpression and WHO grade were the factors affecting poor prognosis.Conclusion The high expression of GSK-3βis related to the poor prognosis of glioma patients,and it is an independent predictor of poor prognosis.

关 键 词：胶质瘤 糖原合成酶激酶-3Β 预后 免疫组化 

分 类 号：R739.4[医药卫生—肿瘤]