结肠癌组织中miR-21、C-met的表达及临床意义  

Expression and clinical significance of miR-21 and C-met in colon cancer

作　　者：刘杰 张文天 杜锦波 LIU Jie;ZHANG Wentian;DU Jinbo(Department of Gastrointestinal Surgery,Cangzhou People's Hospital,Hebei Province,Cangzhou 061000,China)

机构地区：[1]河北省沧州市人民医院胃肠外科,河北沧州061000

出　　处：《中国医药导报》2020年第17期121-124,共4页China Medical Herald

基　　金：河北省卫生计生委医学科学研究课题(20170736);河北省沧州市重点研发计划指导项目(172302047)。

摘　　要：目的探究结肠癌组织中微小RNA(miR)-21和肝细胞生长因子受体(C-met)的表达情况及临床意义。方法回顾性分析2017年2月~2019年5月河北省沧州市人民医院收治的95例结肠癌患者的病理及临床资料。通过荧光实时定量PCR技术定量检测miR-21和C-met在结肠癌组织及其癌旁正常组织中的表达量并比较分析其与临床病理的联系,分析癌组织中miR-21和C-met的相关性。结果结肠癌组织中miR-21和C-met的表达量均高于对应癌旁正常组织(P <0.05)。结肠癌组织中miR-21和C-met的表达与TNM分期、淋巴结转移及脉管癌栓有关(P <0.05)。结肠癌组织中miR-21的表达量和C-met的表达量呈显著正相关(r=0.832,P=0.000)。结论结肠癌组织中C-met和miR-21的表达均上调,且与TNM分期、淋巴结转移及脉管癌栓有关,二者均可能成为评估病情严重程度及预后情况的潜在标志物。Objective To investigate the expression and clinical significance of microRNA(miR)-21 and hepatocyte growth factor receptor(C-met)in colon cancer tissues.Methods The pathological and clinical data of 95 cases with colon cancer who admitted to Cangzhou People′s Hospital of Hebei Province from February 2017 to May 2019 were analyzed retrospectively.Quantitative real-time PCR was used to quantitatively detect the expression levels of miR-21 and C-met in colon cancer tissues and adjacent normal tissues,and their correlation with clinicopathology were analyzed,and the correlation between miR-21 and C-met in cancer tissues was analyzed.Results The expressions of miR-21 and C-met in colon cancer tissues were higher than those in adjacent normal tissues(P<0.05).The expressions of miR-21 and C-met in colon cancer tissues were related to TNM stage,lymph node metastasis and vascular cancer embolus(P<0.05).There was a significant positive correlation between miR-21 expression and C-met expression in colon cancer tissues(r=0.832,P=0.000).Conclusion The expressions of C-met and miR-21 in colon cancer tissues are both up-regulated,and are associated with TNM stage,lymph node metastasis and vascular cancer embolus,which may be potential markers for assessing the severity of the disease and prognosis.

关 键 词：结肠癌 微小RNA-21 肝细胞生长因子受体 相关性 

分 类 号：R735[医药卫生—肿瘤]