胞二磷胆碱联合血塞通注射液治疗ACI患者疗效及其对血清TLR4/NF-κB信号通路水平的作用  

Efficacy of Citicoline Combined with Xuesaitong Injection in Patients with Acute Cerebral Infarction and Effect on the level of Serum TLR4/NF-κB Signaling Pathway

作　　者：肖淑红[1] 刘建浩[2] 王波海 XIAO Shuhong;LIU Jianhao;WANG Bohai(Department of Internal Medicine,Sanya Hospital,Sanya,Hainan,China,572000;Department of Acupunc-ture and moxibustion,Sanya,Hainan,China,572000;Department of Neurology,Second People's Hospital,Shaoyang,Hunan,China,422001)

机构地区：[1]海南省三亚市中医院内科,海南三亚572000 [2]海南省三亚市中医院针灸科,海南三亚572000 [3]湖南省邵阳市第二人民医院神经内科,湖南邵阳422001

出　　处：《分子诊断与治疗杂志》2020年第6期737-740,745,共5页Journal of Molecular Diagnostics and Therapy

基　　金：海南省自然基金(817399)。

摘　　要：目的探讨胞二磷胆碱联合血塞通注射液治疗急性脑梗塞(ACI)患者疗效及对血清Toll样受体4(TLR4)/核因子-κB(NF-κB)信号通路水平的作用。方法应用前瞻性随机对照研究方法选取2015年6月至2019年12月本院ACI患者117例,以计算机生成的随机数字表将患者分为联合组、对照A组、对照B组,各39例。常规治疗基础上,对照A组给予胞二磷胆碱,对照B组给予血塞通注射液,联合组给予胞二磷胆碱联合血塞通注射液,均治疗14 d。比较3组疗效与治疗前、治疗14 d后血液流变学指标(全血低切黏度、全血高切黏度、血浆黏度、纤维蛋白原)、TLR4/NF-κB信号通路水平。结果联合组治疗14 d后总有效率高于对照A组、对照B组,差异有统计学意义(P<0.05);3组治疗14 d后全血低切黏度、全血高切黏度、血浆黏度、纤维蛋白原、血清TLR4、NF-κB P65蛋白水平较治疗前下降,且联合组低于对照A组、对照B组,差异有统计学意义(P<0.05)。结论应用胞二磷胆碱联合血塞通注射液治疗ACI可改善血液流变学情况,抑制TLR4/NF-κB信号通路,疗效显著。Objective To investigate the efficacy of citicoline and Xuesaitong injection in the treatment of patients with acute cerebral infarction(ACI)and effect on the level of serum Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathway.Methods A prospective randomized controlled study was used to select 117 patients with ACI in our hospital from June 2015 to December 2019.The patients were divided into a combined group,a control group A and a control group B by a computer-generated random number table,39 cases each.On the basis of routine treatment,control group A was given citicoline,control group B was given Xuesaitong injection,and combination group was given citicoline combined with Xuesaitong injection,and all were treated for 14 days.The curative effect,the blood rheology indexes(whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,fibrinogen)and TLR4/NF-κB signaling pathway levels before and after 14 days of treatment of the three groups was compared.Results After 14 days of treatment,the total effective rate of the combination group was higher than that of control group A and control group B,the difference was statistically significant(P<0.05);after 14 days of treatment,the levels of whole blood low shear viscosity,whole blood high shear viscosity,plasma viscosity,fibrinogen,serum TLR4 and NF-κB P65 protein in the three groups decreased compared with before treatment,and the combination group was lower than the control group A and control group B,the difference was statistically significant(P<0.05).Conclusion The application of citicoline combined with Xuesaitong injection in the treatment of ACI can improve the hemorheology and inhibit the TLR4/NF-κB signaling pathway,and has a significant effect.

关 键 词：胞二磷胆碱 血塞通注射液 急性脑梗塞 TLR4/NF-κB信号通路 血液流变学 

分 类 号：R743.33[医药卫生—神经病学与精神病学]