AAG、CD64指数和IL-10对肺癌术后并发感染的预测价值及与转归情况关联性  

The predictive value of AAG,CD64 index,and IL-10 in the postoperative infection of lung cancer and its correlation with outcome

作　　者：姜淮[1] 刘金山[1] 张道忠[1] 李杨亮 JIANG Huai;LIU Jinshan;ZHANG Daozhong;LI Yangliang(Department of cardiothoracic surgery,xinhua hospital,xinhua medical group,Anhui,Huainan,China,232052;Laboratory department of xinhua hospital,Huainan,Anhui,China,232052)

机构地区：[1]安徽省淮南市新华医疗集团新华医院心胸外科,安徽淮南232052 [2]安徽省淮南市新华医疗集团新华医院检验科,安徽淮南232052

出　　处：《分子诊断与治疗杂志》2020年第6期751-755,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省淮南市科技局项目(2015A2412)。

摘　　要：目的探究血清α1-酸性糖蛋白(AAG)、CD64指数和白细胞介素-10(IL-10)对肺癌术后并发感染的预测价值及与转归情况关联性。方法选取2014年10月至2019年12月安徽省淮南市新华医疗集团新华医院肺癌术后并发感染患者120例为感染组,同期术后未发生感染患者120例为未感染组。比较两组间、感染组不同转归情况(生存、死亡)患者术前、术后3、7 d血清AAG、CD64指数、IL-10水平;绘制受试者工作特征(ROC)曲线分析血清各指标单一与联合检测对肺癌术后并发感染的预测价值;并统计感染组不同转归情况患者一般资料。结果感染组术后3、7 d血清AAG、CD64指数、IL-10水平均高于未感染组,差异有统计学意义(P<0.05);感染组患者血清AAG、CD64指数、IL-10水平至术后3 d到达峰值,术后3 d血清AAG、CD64指数、IL-10联合预测肺癌术后并发感染的曲线下面积(AUC)为0.862,大于各指标单一预测的AUC,联合预测的最佳预测敏感度为70.00%、特异度为87.50%;感染组死亡、生存患者术前血清AAG、CD64指数、IL-10水平相比,差异无统计学意义(P>0.05);死亡患者术后3、7 d血清AAG、CD64指数、IL-10水平均高于生存患者,差异有统计学意义(P<0.05)。结论肺癌术后感染患者血清AAG、CD64指数、IL-10水平呈异常高表达状态,术后第3 d达到峰值,在预测感染发生方面具有较高应用价值,且与患者不良预后关系密切,明确其变化可为临床制定治疗方案提供参考。Objective To explore the predictive value of serumα1-acid glycoprotein(AAG),CD64 index,and interleukin-10(IL-10)in the postoperative complications of lung cancer and its correlation with outcome.Methods From October 2014 to December 2019,120 patients with the postoperative lung cancer infection in our hospital were selected as the infection group,and 120 patients without infection during the same period were selected as the uninfected group.The serum AAG,CD64 index,and IL-10 levels of pa-tients with different outcomes(survival,death)in the two groups and the infection group before,3 days and 7 days after surgery were measured and compared.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of single and combined detection of serum indicators for the postoperative infec-tions of lung cancer,and general statistics of patients with different outcomes in the infection group were col-lected,Logistic regression analysis was used to explore the influencing factors of death in patients with lung cancer complicated by infection.Results The levels of serum AAG,CD64 index,and IL-10 were higher in the infected group than in the uninfected group at 3 and 7 days after surgery(P<0.05);the levels of serum AAG,CD64 index,and IL-10 in patients in the infection group reached their peaks at 3 days after surgery,the area under the curve(AUC)of serum AAG,CD64 index,and IL-10 combined to predict the postopera-tive infection of lung cancer at 3 days after surgery was 0.862,which was greater than the AUC predicted by each indicator,the best prediction sensitivity of the combined prediction was 70.00%and the specificity was 87.50%;serum AAG,CD64 index,and IL-10 levels were higher in dead patients in the infection group than in surviving patients at 3 and 7 days after surgery(P<0.05);the difference in serum AAG,CD64 index,and IL-10 levels between the death and survival patients in the infection group at 7 days after operation was the greatest,3 days and 7 days after operation were risk factors for dea

关 键 词：肺癌 术后感染 Α1-酸性糖蛋白 CD64指数 白细胞介素-10 疾病转归 

分 类 号：R734.2[医药卫生—肿瘤]