重度低龄儿童龋患者铁锌铜及维生素D的血清水平  

Serum levels of iron,zinc,copper and vitamin D in severe early childhood caries

作　　者：朱少军 热娜·买买提[2] 张蓓[1] 王智亨 葛金莲[3] 刘奕杉[1] ZHU Shaojun;RENA·Mai⁃maiti;ZHANG Bei;WANG Zhiheng;GE Jinlian;LIU Yishan(Department of Pediatric and Preventive Den⁃tistry,The First Affiliated Hospital of Xinjiang Medical University(Affiliated Stomatological Hospital),Urumqi 830054,China;The Child Health Department of the Xinjiang Medical University Health Management Center,Urumqi 830054,China;Department of Clinical Laboratory,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科,新疆维吾尔自治区乌鲁木齐830054 [2]新疆医科大学健康管理中心儿童保健科,新疆维吾尔自治区乌鲁木齐830054 [3]新疆医科大学第一附属医院检验中心,新疆维吾尔自治区乌鲁木齐830054

出　　处：《口腔疾病防治》2020年第8期506-509,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金项目(81560178)。

摘　　要：目的调查及分析重度低龄儿童龋(severe early childhood caries,S-ECC)患者中铁、锌、铜微量元素及维生素D的血清水平,为S-ECC儿童的一级预防及诊疗提供参考。方法选取2018年6月~2019年6月就诊于新疆医科大学健康管理中心儿童保健科儿童(3~5岁)184例,分为无龋组(caries free,CF)(n=89)和S-ECC组(n=95),抽血检测其铁、锌、铜3项微量元素及25羟维生素D的含量。结果 CF组与S-ECC组铁的血清含量为(8.36±0.42)mmol/L、(8.13±0.44)mmol/L,差异有统计学意义(t=3.50,P <0.001);锌的血清含量为(83.18±7.28)μmol/L、(79.23±6.38)μmol/L,差异有统计学意义(t=3.92,P <0.001);25羟维生素D的血清含量为(86.72±15.83)nmol/L、(77.75±11.38)nmol/L,差异有统计学意义(t=4.42,P <0.001);铜的血清含量为(20.18±4.84)μmol/L、(19.49±4.62)μmol/L,但差异无统计学意义(t=0.97,P=0.33)。结论 S-ECC患者血清中铁、锌及维生素D的含量较低,提示在S-ECC的防治过程中应重视铁、锌及维生素D的补充。Objective The serum levels of iron,zinc,copper and vitamin D in severe early childhood caries(S⁃ECC)patients were investigated and analyzed to provide reference for primary prevention and diagnosis of S⁃ECC children.Methods A total of 184 children were enrolled in the Children Health Department of Xinjiang Medical Uni⁃versity Health Management Center from June 2018 to June 2019.They were divided into the caries⁃free(CF)group(n=89)and S⁃ECC group(n=95).The contents of iron,zinc,copper and vitamin D were detected.Results The serum iron content of the CF group and S⁃ECC group was(8.36±0.42)mmol/L and(8.13±0.44)mmol/L,respectively,and the difference was statistically significant(t=3.50,P<0.001);the serum content of zinc was(83.18±7.28)μmol/L and(79.23±6.38)μmol/L,respectively,and the difference was statistically significant(t=3.92,P<0.001);the serum content of 25⁃hydroxyvitamin D was (86.72 ± 15.83) nmol/L and (77.75 ± 11.38) nmol/L, respectively, and the differ⁃ence was statistically significant (t=4.42, P < 0.001). The serum copper content of CF group and S⁃ECC group was(20.18 ± 4.84) μmol/L and (19.49 ± 4.62) μmol/L, but the difference was not statistically significant (t=0.97, P=0.33). Conclusion The contents of iron, zinc and vitamin D in the serum of S⁃ECC patients are low, suggesting thatiron, zinc and vitamin D supplementation should be emphasized in the prevention and treatment of S⁃ECC.

关 键 词：重度低龄儿童龋 乳牙龋齿 微量元素 铁 锌 铜 维生素D 一级预防 

分 类 号：R788[医药卫生—口腔医学]