深圳地区新生儿先天性甲状腺功能减低症的筛查分析  

Neonatal screening of congenital hypothyroidism in in Shenzhen city

作　　者：周逵[1] 李海飞[2] 李素丽[2] ZHOU Kui;LI Hai-fei;LI Su-li(Shenzhen Hospital of Peking University,Shenzhen 518036,China;Shenzhen Women and Children Hospital,Nanfang Medical University,Shenzhen 518048,China)

机构地区：[1]北京大学深圳医院,广东深圳518036 [2]南方医科大学附属深圳市妇幼保健院,广东深圳518048

出　　处：《广东医科大学学报》2020年第3期364-366,共3页Journal of Guangdong Medical University

基　　金：深圳市科技计划项目(No.JCYJ20160427190959898)。

摘　　要：目的 了解深圳地区新生儿先天性甲状腺功能减低症(CH)的筛查情况.方法 采用酶免疫荧光分析法筛查深圳地区2016年1月至2019年11月出生的110 284例新生儿血促甲状腺激素(TSH)水平,疑似CH者测定血清游离甲状腺素(FT4)和TSH水平.结果 CH初筛阳性365例(0.33%),确诊102例(0.09%).低或巨大体质量儿CH检出率均明显高于正常体质量儿,早产儿和过期产儿CH检出率也较足月产儿明显升高,多胎儿CH检出率亦高于单胎儿(P<0.05).结论 早产儿、低或巨大体质量儿、多胎新生儿应进行CH筛查.Objective To screen the congenital hypothyroidism(CH) among newborns in Shenzhen city. Methods From January 2016 to November 2019, blood level of thyroid stimulating hormone(TSH) was determined by enzyme immunofluorescence in 110 284 newborns born in Shenzhen city. Serum levels of free thyroxine(FT4) and TSH were further detected in suspected CH cases. Results Of 110 284 neonates, positive screening and definite diagnosis of CH occurred in 365(0.33%) and 102(0.09%) cases. Detection rate of CH in low birth weight neonates and macrosomia, premature/postterm neonates, and multiple fetuses was higher than that in normal birth weight, full-term, and single neonates, respectively(P<0.05). Conclusion CH screening should be made in premature and low birth weight neonates, macrosomia, and multiple fetuses.

关 键 词：先天性甲状腺功能减低症 新生儿 

分 类 号：R581.2[医药卫生—内分泌] R722.ll[医药卫生—内科学]